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Proceedings Paper

Multispectral fluorescence diffuse optical tomography
Author(s): Pei-An Lo; Jaedu Cho; Farouk Nouizi; Huihua Kenny Chiang; Gultekin Gulsen
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Paper Abstract

Fluorescence diffuse optical tomography (FDOT) has been widely used for in vivo small animal studies and the illposed problem in reconstruction can be eased by utilizing structural a priori obtained from an anatomic imaging modality. In this study, a multispectral fluorescence tomography (FT) is used, which has shown the ability to detect subtle shifts in the ICG absorption spectrum in our previous study. The imaging system is in trans-illumination mode with a swept-wavelength laser and a CCD on a rotation gantry and the structural image from the X-ray computed tomography is used to guide and constrain the FT reconstruction algorithm. In this work, a phantom with two inclusions filled with different fluorophores is utilized to evaluate whether the spectral information obtained using sweptwavelength laser can distinguish these two inclusions. The images are captured from 8 different views with three different wavelengths.

Paper Details

Date Published: 14 March 2017
PDF: 5 pages
Proc. SPIE 10056, Design and Quality for Biomedical Technologies X, 100560Z (14 March 2017); doi: 10.1117/12.2251363
Show Author Affiliations
Pei-An Lo, National Yang-Ming Univ. (Taiwan)
Jaedu Cho, Ctr. for Functional Onco-Imaging, Univ. of California, Irvine (United States)
Farouk Nouizi, Ctr. for Functional Onco-Imaging, Univ. of California, Irvine (United States)
Huihua Kenny Chiang, National Yang Ming Univ. (Taiwan)
Gultekin Gulsen, Ctr. for Functional Onco-Imaging, Univ. of California, Irvine (United States)


Published in SPIE Proceedings Vol. 10056:
Design and Quality for Biomedical Technologies X
Ramesh Raghavachari; Rongguang Liang, Editor(s)

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