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Proceedings Paper

Balance the nodule shape and surroundings: a new multichannel image based convolutional neural network scheme on lung nodule diagnosis
Author(s): Wenqing Sun; Bin Zheng; Xia Huang; Wei Qian
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Paper Abstract

Deep learning is a trending promising method in medical image analysis area, but how to efficiently prepare the input image for the deep learning algorithms remains a challenge. In this paper, we introduced a novel artificial multichannel region of interest (ROI) generation procedure for convolutional neural networks (CNN). From LIDC database, we collected 54880 benign nodule samples and 59848 malignant nodule samples based on the radiologists’ annotations. The proposed CNN consists of three pairs of convolutional layers and two fully connected layers. For each original ROI, two new ROIs were generated: one contains the segmented nodule which highlighted the nodule shape, and the other one contains the gradient of the original ROI which highlighted the textures. By combining the three channel images into a pseudo color ROI, the CNN was trained and tested on the new multichannel ROIs (multichannel ROI II). For the comparison, we generated another type of multichannel image by replacing the gradient image channel with a ROI contains whitened background region (multichannel ROI I). With the 5-fold cross validation evaluation method, the CNN using multichannel ROI II achieved the ROI based area under the curve (AUC) of 0.8823±0.0177, compared to the AUC of 0.8484±0.0204 generated by the original ROI. By calculating the average of ROI scores from one nodule, the lesion based AUC using multichannel ROI was 0.8793±0.0210. By comparing the convolved features maps from CNN using different types of ROIs, it can be noted that multichannel ROI II contains more accurate nodule shapes and surrounding textures.

Paper Details

Date Published: 3 March 2017
PDF: 7 pages
Proc. SPIE 10134, Medical Imaging 2017: Computer-Aided Diagnosis, 101343L (3 March 2017); doi: 10.1117/12.2251297
Show Author Affiliations
Wenqing Sun, Univ. of Texas at El Paso (United States)
Bin Zheng, Univ. of Oklahoma (United States)
Northeastern Univ. (China)
Xia Huang, Univ. of Texas at El Paso (United States)
Wei Qian, Univ. of Texas at El Paso (United States)
Northeastern Univ. (China)

Published in SPIE Proceedings Vol. 10134:
Medical Imaging 2017: Computer-Aided Diagnosis
Samuel G. Armato III; Nicholas A. Petrick, Editor(s)

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