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Proceedings Paper

Antivascular effect induced by photo-mediated ultrasound
Author(s): Xinmai Yang; Zizhong Hu; Haonan Zhang; Aghapi Mordovanakis; Yannis M. Paulus; Xueding Wang
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Paper Abstract

We developed a novel localized antivascular method, namely photo-mediated ultrasound therapy (PUT), by applying synchronized laser and ultrasound pulses. PUT relies on high optical contrast among biological tissues. Taking advantage of the high optical absorption of hemoglobin, PUT can selectively target microvessels without causing unwanted damages to the surrounding tissue. Moreover, PUT working at different optical wavelengths can selectively treat veins or arteries by utilizing the contrast in the optical spectra between deoxy- and oxy-hemoglobin. Through our experiments, we demonstrated that cavitation might have played a key role in PUT. The addition of a laser pulse to an existing ultrasound field can significantly improve the likelihood of inertial cavitation, which can induce microvessel damage through its mechanical effect. In comparison with conventional laser therapies, such as photothermolysis and photocoagulation, the laser energy level needed in PUT is significantly lower. When a nanosecond laser was used, our in vivo experiments showed that the needed laser fluence was in the range of 4 to 40 mJ/cm2.

Paper Details

Date Published: 15 February 2017
PDF: 9 pages
Proc. SPIE 10062, Optical Interactions with Tissue and Cells XXVIII, 100620F (15 February 2017); doi: 10.1117/12.2251281
Show Author Affiliations
Xinmai Yang, The Univ. of Kansas (United States)
Zizhong Hu, Univ. of Michigan (United States)
Haonan Zhang, Univ. of Michigan (United States)
Aghapi Mordovanakis, Univ. of Michigan (United States)
Yannis M. Paulus, Univ. of Michigan (United States)
Xueding Wang, Univ. of Michigan (United States)

Published in SPIE Proceedings Vol. 10062:
Optical Interactions with Tissue and Cells XXVIII
E. Duco Jansen; Hope Thomas Beier, Editor(s)

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