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Proceedings Paper

Copper sulfide nanodisk as photoacoustic contrast agent for ovarian tumor detection
Author(s): Junxin Wang; Su-Wen Hsu; Andrea R. Tao; Jesse V. Jokerst
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Paper Abstract

Ultrasound is broadly used in the clinics yet is limited in early cancer detection because of its poor contrast between healthy and diseased tissues. Photoacoustic imaging can improve this limitation and has been extensively studied in pre-clinical models. Contrast agents can help improve the accuracy of diagnosis. We recently reported a novel copper sulfide (CuS) nanodisk with strong directionally-localized surface plasmon resonance in the near infrared region. This plasmonic resonance of nanodisks is tunable by changing the size and aspect ratio of CuS nanodisk. Here, we demonstrate this CuS nanodisk is a strong photoacoustic contrast agent. We prepared CuS nanodisks via a solvent-based synthesis followed by surface modification of poly(ethylene glycol) methyl ether thiol for in vivo applications. These CuS nanodisks can be detected at a concentration as low as 26 pM at 920 nm. Their nanosize and strong photoacoustic response make this novel CuS nanodisk a strong candidate for photoacoustic cancer imaging.

Paper Details

Date Published: 3 March 2017
PDF: 5 pages
Proc. SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 100642D (3 March 2017); doi: 10.1117/12.2251184
Show Author Affiliations
Junxin Wang, Univ. of California, San Diego (United States)
Su-Wen Hsu, Univ. of California, San Diego (United States)
Andrea R. Tao, Univ. of California, San Diego (United States)
Jesse V. Jokerst, Univ. of California, San Diego (United States)

Published in SPIE Proceedings Vol. 10064:
Photons Plus Ultrasound: Imaging and Sensing 2017
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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