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Proceedings Paper

Photothermal therapy combined with dinitrophenyl hapten for the treatment of late stage malignant melanoma
Author(s): Xiaosong Li; Nan Du; Haijun Li; Shan Long; Dianjun Chen; Feifan Zhou; Yuanyuan Xu; Fuli Wang; Wei R. Chen
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Paper Abstract

To evaluate the efficacy and safety of photothermal with dinitrophenyl hapten (DNP) for patients with malignant melanoma (MM), Patients with pathology confirmed stage III or IV MM were enrolled. Seventy-two patients were randomized into two groups, DNP alone group (n=36) and DNP plus photothermal therapy group (n=36). The results showed that the patients in the combination treatment group had longer median progression-free survival time (19.0m vs. 12.0m, p=0.007). No severe adverse events were observed in both groups. Thus, the combination of photothermal therapy and DNP maybe a new therapeutic strategy for patients with advanced MM.

Paper Details

Date Published: 20 February 2017
PDF: 7 pages
Proc. SPIE 10065, Biophotonics and Immune Responses XII, 1006505 (20 February 2017); doi: 10.1117/12.2251090
Show Author Affiliations
Xiaosong Li, Chinese PLA General Hospital (China)
Nan Du, Chinese PLA General Hospital (China)
Haijun Li, Beijing Military Area Command (China)
Shan Long, Chinese PLA General Hospital (China)
Dianjun Chen, Chinese PLA General Hospital (China)
Feifan Zhou, Univ. of Central Oklahoma (United States)
Yuanyuan Xu, Chinese PLA General Hospital (China)
Fuli Wang, Chinese PLA General Hospital (China)
Wei R. Chen, Univ. of Central Oklahoma (United States)

Published in SPIE Proceedings Vol. 10065:
Biophotonics and Immune Responses XII
Wei R. Chen, Editor(s)

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