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Proceedings Paper

Spectroscopic analysis of autofluorescence distribution in digestive organ for unstained metabolism-based tumor detection
Author(s): Hidenobu Arimoto; Atsushi Iwata; Keiichiro Kagawa; Yoji Sanomura; Shigeto Yoshida; Shoji Kawahito; Shinji Tanaka
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Paper Abstract

Auto fluorescence distribution of coenzymes NADH and FAD is investigated for the unstained tumor detection using an [?] originally designed confocal spectroscope. The tumor region in digestive organ can be determined by evaluating the redox index which is defined as the raio of NADH and FAD concentration. However, the redox index is largely influenced by the presence of collagen in the submucosal layer because its auto fluorescence spectrum overlaps considerably with that of NADH. Therefore, it is necessary to know in advance the distribution of NADH, FAD, and collagen in the mucosal layer. The purpose of our study is to investigate the vertical distribution of the redox index in tissue using depth-sensitive auto fluorescence spectroscopy. The experimental procedure and the results are presented.

Paper Details

Date Published: 16 February 2017
PDF: 6 pages
Proc. SPIE 10068, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XV, 100681L (16 February 2017); doi: 10.1117/12.2250776
Show Author Affiliations
Hidenobu Arimoto, National Institute of Advanced Industrial Science and Technology (Japan)
Atsushi Iwata, Shizuoka Univ. (Japan)
Keiichiro Kagawa, Shizuoka Univ. (Japan)
Yoji Sanomura, Hiroshima Univ. Hospital (Japan)
Shigeto Yoshida, JR Hiroshima Hospital (Japan)
Shoji Kawahito, Shizuoka Univ. (Japan)
Shinji Tanaka, Hiroshima Univ. Hospital (Japan)

Published in SPIE Proceedings Vol. 10068:
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XV
Daniel L. Farkas; Dan V. Nicolau; Robert C. Leif, Editor(s)

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