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Proceedings Paper

Pulsed laser diode photoacoustic tomography (PLD-PAT) system for fast in vivo imaging of small animal brain
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Paper Abstract

In recent years, high-repetition rate pulsed laser diode (PLD) was used as an alternative to the Nd:YAG lasers for photoacoustic tomography (PAT). The use of PLD makes the overall PAT system, a low-cost, portable, and high frame rate imaging tool for preclinical applications. In this work, we will present a portable in vivo pulsed laser diode based photoacoustic tomography (PLD–PAT) system. The PLD is integrated inside a circular scanning geometry. The PLD can provide near-infrared (∼803 nm) pulses with pulse duration ∼136 ns, and pulse energy ∼1.4 mJ / pulse at 7 kHz repetition rate. The system will be demonstrated for in vivo fast imaging of small animal brain. To enhance the contrast of brain imaging, experiments will be carried out using contrast agents which have strong absorption around laser excitation wavelength. This low-cost, portable small animal brain imaging system could be very useful for brain tumor imaging and therapy.

Paper Details

Date Published: 3 March 2017
PDF: 6 pages
Proc. SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 100645O (3 March 2017); doi: 10.1117/12.2250481
Show Author Affiliations
Paul Kumar Upputuri, Nanyang Technological Univ. (Singapore)
Sandeep Kumar Kalva, Nanyang Technological Univ. (Singapore)
Mohesh Moothanchery, Nanyang Technological Univ. (Singapore)
Manojit Pramanik, Nanyang Technological Univ. (Singapore)

Published in SPIE Proceedings Vol. 10064:
Photons Plus Ultrasound: Imaging and Sensing 2017
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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