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Proceedings Paper

Multi-wavelength time-lens source and its application to nonresonant background suppression for coherent anti-Stokes Raman scattering microscopy
Author(s): Bo Li; Kriti Charan; Ke Wang; David Sinefeld; Chris Xu
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Paper Abstract

We demonstrate a robust, all-fiber, two-wavelength time-lens source for background-free coherent anti-Stokes Raman scattering (CARS) imaging. The time-lens source generates two picosecond pulse trains simultaneously: one at 1064 nm and the other tunable between 1040 nm and 1075 nm (~ 400 mW for each wavelength). When synchronized to a modelocked Ti:Sa laser, the two wavelengths are used to obtain on- and off-resonance CARS images. Real-time subtraction of the nonresonant background in the CARS image is achieved by the synchronization of the pixel clock and the time-lens source. Background-free CARS imaging of sebaceous glands in ex vivo mouse tissue is demonstrated.

Paper Details

Date Published: 21 February 2017
PDF: 5 pages
Proc. SPIE 10069, Multiphoton Microscopy in the Biomedical Sciences XVII, 100690Y (21 February 2017); doi: 10.1117/12.2250347
Show Author Affiliations
Bo Li, Cornell Univ. (United States)
Kriti Charan, Cornell Univ. (United States)
Ke Wang, Shenzhen Univ. (China)
David Sinefeld, Cornell Univ. (United States)
Chris Xu, Cornell Univ. (United States)

Published in SPIE Proceedings Vol. 10069:
Multiphoton Microscopy in the Biomedical Sciences XVII
Ammasi Periasamy; Peter T. C. So; Karsten König; Xiaoliang S. Xie, Editor(s)

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