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Proceedings Paper

Skin cancer margin analysis within minutes with full-field OCT (Conference Presentation)
Author(s): Eugénie Dalimier; Lauren Ogrich; Diego Morales; Carrie Ann Cusack; Mark Abdelmalek; Claude Boccara; John Durkin

Paper Abstract

Non-melanoma skin cancer (NMSC) is the most common cancer. Treatment consists of surgical removal of the skin cancer. Traditional excision involves the removal of the visible skin cancer with a significant margin of normal skin. On cosmetically sensitive areas, Mohs micrographic tissue is the standard of care. Mohs uses intraoperative microscopic margin assessment which minimizes the surgical defect and can help reduce the recurrence rate by a factor of 3. The current Mohs technique relies on frozen section tissue slide preparation which significantly lengthens operative time and requires on-site trained histotechnicians. Full-Field Optical Coherence Tomography (FFOCT) is a novel optical imaging technique which provides a quick and efficient method to visualize cancerous areas in minutes, without any preparation or destruction of the tissue. This study aimed to evaluate the potential of FFOCT for the analysis of skin cancer margins during Mohs surgery. Over 150 images of Mohs specimens were acquired intraoperatively with FFOCT before frozen section analysis. The imaging procedure took less than 5 minutes for each specimen. No artifacts on histological preparation were found arising from FFOCT manipulation; however frozen section artifact was readily seen on FFOCT. An atlas was established with FFOCT images and corresponding histological slides to reveal FFOCT reading criteria of normal and cancerous structures. Blind analysis showed high concordance between FFOCT and histology. FFOCT can potentially reduce recurrence rates while maintaining short surgery times, optimize clinical workflow, and decrease healthcare costs. For the patient, this translates into smaller infection risk, decreased stress, and better comfort.

Paper Details

Date Published: 19 April 2017
PDF: 1 pages
Proc. SPIE 10037, Photonics in Dermatology and Plastic Surgery, 100370A (19 April 2017); doi: 10.1117/12.2250292
Show Author Affiliations
Eugénie Dalimier, LLTech SAS (France)
Lauren Ogrich, Drexel Univ. College of Medicine (United States)
Diego Morales, Drexel Univ. College of Medicine (United States)
Carrie Ann Cusack, Drexel Univ. College of Medicine (United States)
Mark Abdelmalek, Drexel Univ. College of Medicine (United States)
Claude Boccara, LLTech SAS (France)
John Durkin, Drexel Univ. College of Medicine (United States)

Published in SPIE Proceedings Vol. 10037:
Photonics in Dermatology and Plastic Surgery
Bernard Choi; Haishan Zeng; Nikiforos Kollias, Editor(s)

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