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Proceedings Paper

Functional near infrared spectroscopy for awake monkey to accelerate neurorehabilitation study
Author(s): Hiroshi Kawaguchi; Noriyuki Higo; Junpei Kato; Keiji Matsuda; Toru Yamada
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Paper Abstract

Functional near-infrared spectroscopy (fNIRS) is suitable for measuring brain functions during neurorehabilitation because of its portability and less motion restriction. However, it is not known whether neural reconstruction can be observed through changes in cerebral hemodynamics. In this study, we modified an fNIRS system for measuring the motor function of awake monkeys to study cerebral hemodynamics during neurorehabilitation. Computer simulation was performed to determine the optimal fNIRS source–detector interval for monkey motor cortex. Accurate digital phantoms were constructed based on anatomical magnetic resonance images. Light propagation based on the diffusion equation was numerically calculated using the finite element method. The source–detector pair was placed on the scalp above the primary motor cortex. Four different interval values (10, 15, 20, 25 mm) were examined. The results showed that the detected intensity decreased and the partial optical path length in gray matter increased with an increase in the source-detector interval. We found that 15 mm is the optimal interval for the fNIRS measurement of monkey motor cortex. The preliminary measurement was performed on a healthy female macaque monkey using fNIRS equipment and custom-made optodes and optode holder. The optodes were attached above bilateral primary motor cortices. Under the awaking condition, 10 to 20 trials of alternated single-sided hand movements for several seconds with intervals of 10 to 30 s were performed. Increases and decreases in oxy- and deoxyhemoglobin concentration were observed in a localized area in the hemisphere contralateral to the moved forelimb.

Paper Details

Date Published: 8 February 2017
PDF: 8 pages
Proc. SPIE 10051, Neural Imaging and Sensing, 1005117 (8 February 2017); doi: 10.1117/12.2250080
Show Author Affiliations
Hiroshi Kawaguchi, National Institute of Advanced Industrial Science and Technology (Japan)
Noriyuki Higo, National Institute of Advanced Industrial Science and Technology (Japan)
Junpei Kato, National Institute of Advanced Industrial Science and Technology (Japan)
Univ. of Tsukuba (Japan)
Keiji Matsuda, National Institute of Advanced Industrial Science and Technology (Japan)
Toru Yamada, National Institute of Advanced Industrial Science and Technology (Japan)

Published in SPIE Proceedings Vol. 10051:
Neural Imaging and Sensing
Qingming Luo; Jun Ding, Editor(s)

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