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Proceedings Paper

A monomeric water-soluble NIR-absorbing porphyrin derivative as in vivo photoacoustic tomography contrast agent
Author(s): Mohsen Erfanzadeh; Michael Luciano; Feifei Zhou; Christian Brückner; Quing Zhu
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Paper Abstract

A PEGylated quinoline-annulated porphyrin derivative was synthesized as in vivo photoacoustic tomography contrast agent. It possesses high solubility and stability in water and phosphate-buffered saline. No toxicity sign was observed in BALB/c mice. The dye demonstrates a 4-fold higher photoacoustic signal generation efficiency compared to fresh rat blood. Injection of the dye results in a significant enhancement of in vivo PAT images of murine tumors. Analysis of the mouse urine after injection revealed an unaltered renal filtration of the contrast agent.

Paper Details

Date Published: 3 March 2017
PDF: 7 pages
Proc. SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 1006432 (3 March 2017); doi: 10.1117/12.2249877
Show Author Affiliations
Mohsen Erfanzadeh, Univ. of Connecticut (United States)
Michael Luciano, Univ. of Connecticut (United States)
Feifei Zhou, Univ. of Connecticut (United States)
Christian Brückner, Univ. of Connecticut (United States)
Quing Zhu, Washington Univ. in St. Louis (United States)

Published in SPIE Proceedings Vol. 10064:
Photons Plus Ultrasound: Imaging and Sensing 2017
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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