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Proceedings Paper

Cancer cell death processes in combining photothermal and photodynamic effects through surface plasmon resonance of gold nanoring (Conference Presentation)
Author(s): Yulu He; Jian-He Yu; Jen-Hung Hsiao; Yi-Chou Tu; Meng Chun Low; Wei-Hsiang Hua; Cheng-Che Hsieh; Yean-Woei Kiang; Chih-Chung Yang; Zhenxi Zhang

Paper Abstract

In combining the photothermal and photodynamic effects for killing cancer cells through the localized surface plasmon resonance (LSP) of photosensitizer-linked Au nanorings (NRIs), which are up-taken by the cells, the cells can be killed via different processes, including necrosis and apoptosis. In particular, the dominating effect, either photothermal or photodynamic effect, for cancer cell killing leading to either necrosis or apoptosis process is an important issue to be understood for improving the therapy efficiency. In this paper, we demonstrate the study results in differentiating the necrosis and apoptosis processes of cell death under different laser illumination conditions. With the LSP resonance wavelength of the Au NRIs around 1064 nm, the illumination of a 1064-nm cw laser can mainly produce the photothermal effect. The illumination of a 1064-nm fs laser can lead to LSP resonance-assisted two-photon absorption of the photosensitizer (AlPcS) for generating singlet oxygen and hence the photodynamic effect, besides the photothermal effect. Also, the illumination of a 660-nm cw laser can result in single-photon absorption of the photosensitizer for generating singlet oxygen and the photodynamic effect. By comparing the necrosis and apoptosis distributions in dead cells between the cases of different laser illumination conditions, we can differentiate the cancer cell killing processes between the photothermal effect, photodynamic effect, and the mixed effect.

Paper Details

Date Published: 24 April 2017
PDF: 1 pages
Proc. SPIE 10078, Colloidal Nanoparticles for Biomedical Applications XII, 1007811 (24 April 2017); doi: 10.1117/12.2249543
Show Author Affiliations
Yulu He, Xi'an Jiaotong Univ. (China)
National Taiwan Univ. (Taiwan)
Jian-He Yu, National Taiwan Univ. (Taiwan)
Jen-Hung Hsiao, National Taiwan Univ. (Taiwan)
Yi-Chou Tu, National Taiwan Univ. (Taiwan)
Meng Chun Low, National Taiwan Univ. (Taiwan)
Wei-Hsiang Hua, National Taiwan Univ. (Taiwan)
Cheng-Che Hsieh, National Taiwan Univ. (Taiwan)
Yean-Woei Kiang, National Taiwan Univ. (Taiwan)
Chih-Chung Yang, National Taiwan Univ. (Taiwan)
Zhenxi Zhang, Xi'an Jiaotong Univ. (China)

Published in SPIE Proceedings Vol. 10078:
Colloidal Nanoparticles for Biomedical Applications XII
Marek Osiński; Wolfgang J. Parak; Xing-Jie Liang, Editor(s)

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