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Proceedings Paper

Optical monitoring of kidney oxygenation and hemodynamics using a miniaturized near-infrared sensor
Author(s): Babak Shadgan; Andrew Macnab; Mark Nigro; Christopher Nguan
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Paper Abstract

Background: Following human renal allograft transplant primary graft dysfunction can occur early in the postoperative period as a result of acute tubular necrosis, acute rejection, drug toxicity, and vascular complications. Successful treatment of graft dysfunction requires early detection and accurate diagnosis so that disease-specific medical and/or surgical intervention can be provided promptly. However, current diagnostic methods are not sensitive or specific enough, so that identifying the cause of graft dysfunction is problematic and often delayed. Near-infrared spectroscopy (NIRS) is an established optical method that monitors changes in tissue hemodynamics and oxygenation in real time. We report the feasibility of directly monitoring kidney the kidney in an animal model using NIRS to detect renal ischemia and hypoxia. Methods: In an anesthetized pig, a customized continuous wave spatially resolved (SR) NIRS sensor was fixed directly to the surface of the surgically exposed kidney. Changes in the concentration of oxygenated (O2Hb) deoxygenated (HHb) and total hemoglobin (THb) were monitored before, during and after renal artery clamping and reperfusion, and the resulting fluctuations in chromophore concentration from baseline used to measure variations in renal perfusion and oxygenation. Results: On clamping the renal artery THb and O2Hb concentrations declined progressively while HHb rose. With reperfusion after releasing the artery clamp O2Hb and THb rose while HHb fell with all parameters returning to its baseline. This pattern was similar in all three trials. Conclusion: This pilot study indicates that a miniaturized NIRS sensor applied directly to the surface of a kidney in an animal model can detect the onset of renal ischemia and tissue hypoxia. With modification, our NIRS-based method may contribute to early detection of renal vascular complications and graft dysfunction following renal transplant.

Paper Details

Date Published: 21 February 2017
PDF: 5 pages
Proc. SPIE 10038, Therapeutics and Diagnostics in Urology: Lasers, Robotics, Minimally Invasive, and Advanced Biomedical Devices, 100380I (21 February 2017); doi: 10.1117/12.2246663
Show Author Affiliations
Babak Shadgan, The Univ. of British Columbia (Canada)
Andrew Macnab, The Univ. of British Columbia (Canada)
Wallenberg Research Ctr. (South Africa)
Mark Nigro, The Univ. of British Columbia (Canada)
Christopher Nguan, The Univ. of British Columbia (Canada)

Published in SPIE Proceedings Vol. 10038:
Therapeutics and Diagnostics in Urology: Lasers, Robotics, Minimally Invasive, and Advanced Biomedical Devices
Hyun Wook Kang; Kin Foong Chan, Editor(s)

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