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Proceedings Paper

Amphiphilic block copolymer-based photonic platform towards efficient protein detection
Author(s): Afroditi Petropoulou; Thomas J. Gibson; Efrosyni Themistou; Stergios Pispas; Christos Riziotis
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Paper Abstract

The development of a low complexity fiber optic based protein sensor by functionalizing the surface of silica optical fibers using block copolymers having both hydrophobic poly(methyl methacrylate) (PMMA) and hydrophilic poly[2- (dimethylamino)ethyl methacrylate] (PDMAEMA) blocks is presented here. The amphiphilic thiol-functionalized PMMA117-b-P(DMAEMA17-st-TEMA2) and vinyl-sulfone PMMA117-b-P(DMAEMA17-st-VSTEMA2) block copolymers designed and synthesized in this work contain a cationic hydrophilic PDMAEMA block that can electrostatically bind selected oppositely charged proteins and also appropriate functional groups for reversible or non-reversible protein binding, respectively, leading to a refractive index change of the overlayer and hence, enabling the sensing. The developed PMMA117-b-PDMAEMA16-based platform has been evaluated for bovine serum albumin (BSA) sensing, exhibiting linear response to detected BSA concentrations.

Paper Details

Date Published: 14 November 2016
PDF: 6 pages
Proc. SPIE 10025, Advanced Sensor Systems and Applications VII, 100250M (14 November 2016); doi: 10.1117/12.2246506
Show Author Affiliations
Afroditi Petropoulou, National Hellenic Research Foundation (Greece)
Univ. of Peloponnese (Greece)
Thomas J. Gibson, Queen's Univ. Belfast (United Kingdom)
Efrosyni Themistou, Queen's Univ. Belfast (United Kingdom)
Stergios Pispas, National Hellenic Research Foundation (Greece)
Christos Riziotis, National Hellenic Research Foundation (Greece)

Published in SPIE Proceedings Vol. 10025:
Advanced Sensor Systems and Applications VII
Tiegen Liu; Shibin Jiang; Rene Landgraf, Editor(s)

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