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Proceedings Paper

Gold nano sphere based fiber optic LSPR probe for biosensing measurement
Author(s): Lixia Li; Zigeng Liu; Shimeng Chen; Jianye Guang; Wei Peng
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Paper Abstract

We present a localized surface plasmon resonance fiber optic biosensor based on an intensity interrogation mechanism. A layer of gold nano sphere is deposited on a fiber optic sensor probe which works as the sensing element and is immobilized on the sidewall of an unclad optical fiber via two different immobilization methods (amino silane method and layer by layer self-assembly method). Different self-assembly layers were also respectively investigated by using layer by layer self-assembly method to explore the optimum layer number. Experimental results reveal that PDDA/PSS/PAH layer self-assembly method provides the best LSPR response. We obtain a refractive index sensitivity as 6.57RIU-1 in a RI range of 1.3266~1.3730. We also conduct real-time and label free monitoring of Ribonuclease B/Con A biomolecular interaction by using this sensor prototype and demonstrate it can perform qualitative and quantitative detection in real-time biomolecular sensing.

Paper Details

Date Published: 4 November 2016
PDF: 6 pages
Proc. SPIE 10027, Nanophotonics and Micro/Nano Optics III, 100270M (4 November 2016); doi: 10.1117/12.2245960
Show Author Affiliations
Lixia Li, Dalian Univ. of Technology (China)
Zigeng Liu, Dalian Univ. of Technology (China)
Shimeng Chen, Dalian Univ. of Technology (China)
Jianye Guang, Dalian Univ. of Technology (China)
Wei Peng, Dalian Univ. of Technology (China)

Published in SPIE Proceedings Vol. 10027:
Nanophotonics and Micro/Nano Optics III
Zhiping Zhou; Kazumi Wada, Editor(s)

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