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Proceedings Paper

Polydopamine-coated gold nanostars for CT imaging and enhanced photothermal therapy of tumors
Author(s): Du Li; Xiangyang Shi; Dayong Jin
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Paper Abstract

The advancement of biocompatible nanoplatforms with dual functionalities of diagnosis and therapeutics is strongly demanded in biomedicine in recent years. In this work, we report the synthesis and characterization of polydopamine (pD)-coated gold nanostars (Au NSs) for computed tomography (CT) imaging and enhanced photothermal therapy (PTT) of tumors. Au NSs were firstly formed via a seed-mediated growth method and then stabilized with thiolated polyethyleneimine (PEI-SH), followed by deposition of pD on their surface. The formed pD-coated Au NSs (Au-PEI@pD NSs) were well characterized. We show that the Au-PEI@pD NSs are able to convert the absorbed near-infrared laser light into heat, and have strong X-ray attenuation property. Due to the co-existence of Au NSs and the pD, the light to heat conversion efficiency of the NSs can be significantly enhanced. These very interesting properties allow their uses as a powerful theranostic nanoplatform for efficient CT imaging and enhanced phtotothermal therapy of cancer cells in vitro and the xenografted tumor model in vivo. With the easy functionalization nature enabled by the coated pD shell, the developed pD-coated Au NSs may be developed as a versatile nanoplatform for targeted CT imaging and PTT of different types of cancer.

Paper Details

Date Published: 9 December 2016
PDF: 1 pages
Proc. SPIE 10013, SPIE BioPhotonics Australasia, 100133L (9 December 2016); doi: 10.1117/12.2245310
Show Author Affiliations
Du Li, Donghua Univ. (China)
Univ. of Technology, Sydney (Australia)
Xiangyang Shi, Donghua Univ. (China)
Dayong Jin, Univ. of Technology, Sydney (Australia)

Published in SPIE Proceedings Vol. 10013:
SPIE BioPhotonics Australasia
Mark R. Hutchinson; Ewa M. Goldys, Editor(s)

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