
Proceedings Paper
Magnesium degradation observed in situ under flow by synchrotron radiation based microtomographyFormat | Member Price | Non-Member Price |
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Paper Abstract
The use of degradable magnesium based implants is becoming clinically relevant, e.g. for the use as bone screws. Still
there is a lack of analyzing techniques to characterize the in vitro degradation behavior of implant prototypes. The aim of
this study was to design an in situ environment to continuously monitor the degradation processes under physiological
conditions by time-lapse SRμCT. The use of physiological conditions was chosen to get a better approach to the in vivo
situation, as it could be shown by many studies, that these conditions change on the one hand the degradation rate and on
the other hand also the formed degradation products. The resulting in situ environment contains a closed bioreactor
system to control and monitor the relevant parameters (37°C, 5 % O2, 20 % CO2) and to grant sterility of the setup. A
flow cell was designed and manufactured from polyether etherketone (PEEK), which was chosen because of the good
mechanical properties, high thermal and chemical resistance and radiographic translucency. Sterilization of the system
including the sample was reached by a transient flush with 70 % ethanol and subsequent replacement by physiological
medium (Modified Eagle Medium alpha). As proof of principle it could be shown that the system remained sterile during
a beamtime of several days and that the continuous SRμCT imaging was feasible.
Paper Details
Date Published: 4 October 2016
PDF: 9 pages
Proc. SPIE 9967, Developments in X-Ray Tomography X, 99671X (4 October 2016); doi: 10.1117/12.2241085
Published in SPIE Proceedings Vol. 9967:
Developments in X-Ray Tomography X
Stuart R. Stock; Bert Müller; Ge Wang, Editor(s)
PDF: 9 pages
Proc. SPIE 9967, Developments in X-Ray Tomography X, 99671X (4 October 2016); doi: 10.1117/12.2241085
Show Author Affiliations
Frank Feyerabend, Helmholtz-Zentrum Geesthacht (Germany)
Thomas Dose, Helmholtz-Zentrum Geesthacht (Germany)
Yuling Xu, Helmholtz-Zentrum-Geesthacht (Germany)
Felix Beckmann, Helmholtz-Zentrum Geesthacht (Germany)
Michael Stekker, MeKo Laser Material Processing (Germany)
Thomas Dose, Helmholtz-Zentrum Geesthacht (Germany)
Yuling Xu, Helmholtz-Zentrum-Geesthacht (Germany)
Felix Beckmann, Helmholtz-Zentrum Geesthacht (Germany)
Michael Stekker, MeKo Laser Material Processing (Germany)
Regine Willumeit-Römer, Helmholtz-Zentrum-Geesthacht (Germany)
Andreas Schreyer, Helmholtz-Zentrum-Geesthacht (Germany)
European-Spallation-Source (Sweden)
Fabian Wilde, Helmholtz-Zentrum Geesthacht (Germany)
Jörg U. Hammel, Helmholtz-Zentrum Geesthacht (Germany)
Andreas Schreyer, Helmholtz-Zentrum-Geesthacht (Germany)
European-Spallation-Source (Sweden)
Fabian Wilde, Helmholtz-Zentrum Geesthacht (Germany)
Jörg U. Hammel, Helmholtz-Zentrum Geesthacht (Germany)
Published in SPIE Proceedings Vol. 9967:
Developments in X-Ray Tomography X
Stuart R. Stock; Bert Müller; Ge Wang, Editor(s)
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