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Proceedings Paper

On-a-chip biosensing with nano-optical resonators (Conference Presentation)
Author(s): Romain Quidant; Ozlem Yavas; Vanesa Sanz; Srdjan Acimovic; Paulina Dobosz

Paper Abstract

Optical biosensing based on gold nanoparticles supporting localized surface plasmoncs (LSPR) potentially offers great opportunities for compact, sensitive and low cost diagnostic devices. While last two decades have witnessed a diversity of nanoplasmonic systems with outstanding sensitivity, the implementation of LSPR sensing into a real analytical device is only at its infancy. In this context, we present here our latest advances in the optical, label free detection of biomolecules based on gold nanoantennas integrated into a state-of-the-art microfluidic platform. We first demonstrate the capability of our platform to detect low concentrations (<1ng/ml) of protein cancer markers in human serum with low unspecific binding and high repeatability. In a second step we present a novel design that enables to simultaneously determine the absolute concentration of four different target molecules from an unknown sample. The system is validated in the context of breast cancer, as a strategy to assess the risk for brain metastasis. In the final part of the paper we discuss the use of LSPR sensing for the detection of other targets, including DNA and exosomes. Our research demonstrates the high potential of gold nanoparticles for the detection of different biomarkers in real biological samples and thus gets us closer to future LSPR-based point-of-care devices.

Paper Details

Date Published: 9 November 2016
PDF: 1 pages
Proc. SPIE 9921, Plasmonics: Design, Materials, Fabrication, Characterization, and Applications XIV, 992119 (9 November 2016); doi: 10.1117/12.2238901
Show Author Affiliations
Romain Quidant, ICFO - Institut de Ciències Fotòniques (Spain)
Ozlem Yavas, ICFO - Institut de Ciències Fotòniques (Spain)
Vanesa Sanz, ICFO - Institut de Ciències Fotòniques (Spain)
Srdjan Acimovic, Chalmers Univ. (Sweden)
ICFO - Institut de Ciències Fotòniques (Spain)
Paulina Dobosz, ICFO - Institut de Ciències Fotòniques (Spain)

Published in SPIE Proceedings Vol. 9921:
Plasmonics: Design, Materials, Fabrication, Characterization, and Applications XIV
Satoshi Kawata; Din Ping Tsai, Editor(s)

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