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Proceedings Paper

Cerebral venous circulatory disturbance as an informative prognostic marker for neonatal hemorrhagic stroke
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Paper Abstract

Neonatal hemorrhagic stroke (NHS) is a major problem of future generation’s health due to the high rate of death and cognitive disability of newborns after NHS. The incidence of NHS in neonates cannot be predicted by standard diagnostic methods. Therefore, the identification of prognostic markers of NHS is crucial. There is evidence that stress-related alterations of cerebral blood flow (CBF) may contribute to NHS. Here, we assessed the stroke-associated CBF abnormalities for high prognosis of NHS using a new model of NHS induced by sound stress in the pre- and post-stroke state. With this aim, we used interdisciplinary methods such as a histological assay of brain tissues, laser speckle contrast imaging and Doppler coherent tomography to monitor cerebral circulation. Our results suggest that the venous stasis with such symptoms as progressive relaxation of cerebral veins, decrease the velocity of blood flow in them are prognostic markers for a risk of NHS and are an informative platform for a future study of corrections of cerebral venous circulatory disturbance related to NHS.

Paper Details

Date Published: 27 April 2016
PDF: 6 pages
Proc. SPIE 9887, Biophotonics: Photonic Solutions for Better Health Care V, 98872I (27 April 2016); doi: 10.1117/12.2225489
Show Author Affiliations
Oxana Semyachkina-Glushkovskaya, Saratov State Univ. (Russian Federation)
Alexey Pavlov, Saratov State Univ. (Russian Federation)
Saratov State Technical Univ. (Russian Federation)
Nikita Navolokin, Saratov State Medical Univ. (Russian Federation)
Vladislav Lychagov, Saratov State Univ. (Russian Federation)
Arkady Abdurashitov, Saratov State Univ. (Russian Federation)
Ekaterina Zinchenko, Saratov State Univ. (Russian Federation)
Artemiy Gekaluk, Saratov State Univ. (Russian Federation)
Dan Zhu, Huazhong Univ. of Science and Technology (China)
Rui Shi, Huazhong Univ. of Science and Technology (China)
Qingming Luo, Huazhong Univ. of Science and Technology (China)
Valery Tuchin, Saratov State Univ. (Russian Federation)
Tomsk State Univ. (Russian Federation)

Published in SPIE Proceedings Vol. 9887:
Biophotonics: Photonic Solutions for Better Health Care V
Jürgen Popp; Valery V. Tuchin; Dennis L. Matthews; Francesco Saverio Pavone, Editor(s)

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