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Proceedings Paper

On the possibility of low cost, adherent therapeutic drug monitoring in oncology
Author(s): Silvia Dalla Marta; Stefano Fornasaro; Aleksandra Jaworska; Giuseppe Toffoli; Alois Bonifacio; Valter Sergo
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Paper Abstract

A frequent quantification of drugs concentrations in plasma of patients subject to chemotherapy is seldom performed, mostly because the standard methods (Gas or Liquid Chromatography coupled with Mass Spectroscopy) are expensive and time consuming. In this paper we report the approach pursued in one of the research units of the EU project RAMAN4CLINICS to tackle the problem of a low cost, time adherent quantification of drugs used for oncological patients using a Surface Enhanced Raman Scattering (SERS) spectroscopy. More specifically, the issues concerning the repeatability of the nanostructured substrates will be presented and some promising results to increase the selectivity of the measures toward specific drugs will be discussed, with examples concerning one cytotoxic agent, Irinotecan and one kinase inhibitor, Sunitinib.

Paper Details

Date Published: 2 May 2016
PDF: 6 pages
Proc. SPIE 9887, Biophotonics: Photonic Solutions for Better Health Care V, 98870G (2 May 2016); doi: 10.1117/12.2225232
Show Author Affiliations
Silvia Dalla Marta, Univ. degli Studi di Trieste (Italy)
Stefano Fornasaro, Univ. degli Studi di Trieste (Italy)
Aleksandra Jaworska, Univ. degli Studi di Trieste (Italy)
Giuseppe Toffoli, IRCCS-National Cancer Institute (Italy)
Alois Bonifacio, Univ. degli Studi di Trieste (Italy)
Valter Sergo, Univ. degli Studi di Trieste (Italy)

Published in SPIE Proceedings Vol. 9887:
Biophotonics: Photonic Solutions for Better Health Care V
Jürgen Popp; Valery V. Tuchin; Dennis L. Matthews; Francesco Saverio Pavone, Editor(s)

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