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Proceedings Paper

IGF-1 receptor targeted nanoparticles for image-guided therapy of stroma-rich and drug resistant human cancer
Author(s): Hongyu Zhou; Weiping Qian; Fatih M. Uckun; Zhiyang Zhou; Liya Wang; Andrew Wang; Hui Mao; Lily Yang
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Paper Abstract

Low drug delivery efficiency and drug resistance from highly heterogeneous cancer cells and tumor microenvironment represent major challenges in clinical oncology. Growth factor receptor, IGF-1R, is overexpressed in both human tumor cells and tumor associated stromal cells. The level of IGF-1R expression is further up-regulated in drug resistant tumor cells. We have developed IGF-1R targeted magnetic iron oxide nanoparticles (IONPs) carrying multiple anticancer drugs into human tumors. This IGF-1R targeted theranostic nanoparticle delivery system has an iron core for non-invasive MR imaging, amphiphilic polymer coating to ensure the biocompatibility as well as for drug loading and conjugation of recombinant human IGF-1 as targeting molecules. Chemotherapy drugs, Doxorubicin (Dox), was encapsulated into the polymer coating and/or conjugated to the IONP surface by coupling with the carboxyl groups. The ability of IGF1R targeted theranostic nanoparticles to penetrate tumor stromal barrier and enhance tumor cell killing has been demonstrated in human pancreatic cancer patient tissue derived xenograft (PDX) models. Repeated systemic administrations of those IGF-1R targeted theranostic IONP carrying Dox led to breaking the tumor stromal barrier and improved therapeutic effect. Near infrared (NIR) optical and MR imaging enabled noninvasive monitoring of nanoparticle-drug delivery and therapeutic responses. Our results demonstrated that IGF-1R targeted nanoparticles carrying multiple drugs are promising combination therapy approaches for image-guided therapy of stroma-rich and drug resistant human cancer, such as pancreatic cancer.

Paper Details

Date Published: 17 May 2016
PDF: 7 pages
Proc. SPIE 9836, Micro- and Nanotechnology Sensors, Systems, and Applications VIII, 98361O (17 May 2016); doi: 10.1117/12.2224914
Show Author Affiliations
Hongyu Zhou, Emory Univ. (United States)
Weiping Qian, Emory Univ. (United States)
Fatih M. Uckun, The Univ. of Southern California (United States)
Zhiyang Zhou, Emory Univ. (United States)
Central South Univ. (China)
Liya Wang, Emory Univ. (United States)
Andrew Wang, Ocean NanoTech (United States)
Hui Mao, Emory Univ. (United States)
Lily Yang, Emory Univ. (United States)

Published in SPIE Proceedings Vol. 9836:
Micro- and Nanotechnology Sensors, Systems, and Applications VIII
Thomas George; Achyut K. Dutta; M. Saif Islam, Editor(s)

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