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Proceedings Paper

Towards ultrahigh resting-state functional connectivity in the mouse brain using photoacoustic microscopy
Author(s): Ali Hariri; Nicholas Bely; Chen Chen; Mohammadreza Nasiriavanaki
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Paper Abstract

The increasing use of mouse models for human brain disease studies, coupled with the fact that existing high-resolution functional imaging modalities cannot be easily applied to mice, presents an emerging need for a new functional imaging modality. Utilizing both mechanical and optical scanning in the photoacoustic microscopy, we can image spontaneous cerebral hemodynamic fluctuations and their associated functional connections in the mouse brain. The images is going to be acquired noninvasively with a fast frame rate, a large field of view, and a high spatial resolution. We developed an optical resolution photoacoustic microscopy (OR-PAM) with diode laser. Laser light was raster scanned due to XY-stage movement. Images from ultra-high OR-PAM can then be used to study brain disorders such as stroke, Alzheimer’s, schizophrenia, multiple sclerosis, autism, and epilepsy.

Paper Details

Date Published: 22 March 2016
PDF: 4 pages
Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 97085A (22 March 2016); doi: 10.1117/12.2224888
Show Author Affiliations
Ali Hariri, Wayne State Univ. (United States)
Nicholas Bely, Wayne State Univ. (United States)
Chen Chen, Wayne State Univ. (United States)
Mohammadreza Nasiriavanaki, Wayne State Univ. (United States)
Wayne State Univ. School of Medicine (United States)
Barbara Ann Karmanos Cancer Institute (United States)

Published in SPIE Proceedings Vol. 9708:
Photons Plus Ultrasound: Imaging and Sensing 2016
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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