Share Email Print

Proceedings Paper

Clinical development of BLZ-100 for real-time optical imaging of tumors during resection
Author(s): Heather L. Franklin; Dennis M. Miller; Teresa Hedges; Jeff Perry; Julia Parrish-Novak
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

Complete initial resection can give cancer patients the best opportunity for long-term survival. There is unmet need in surgical oncology for optical imaging that enables simple and precise visualization of tumors and consistent contrast with surrounding normal tissues. Near-infrared (NIR) contrast agents and camera systems that can detect them represent an area of active research and development. The investigational Tumor Paint agent BLZ-100 is a conjugate of a chlorotoxin peptide and the NIR dye indocyanine green (ICG) that has been shown to specifically bind to a broad range of solid tumors. Clinical efficacy studies with BLZ-100 are in progress, a necessary step in bringing the product into clinical practice. To ensure a product that will be useful for and accepted by surgeons, the early clinical development of BLZ- 100 incorporates multiple tumor types and imaging devices so that surgeon feedback covers the range of anticipated clinical uses. Key contrast agent characteristics include safety, specificity, flexibility in timing between dose and surgery, and breadth of tumor types recognized. Imaging devices should use wavelengths that are optimal for the contrast agent, be sensitive enough that contrast agent dosing can be adjusted for optimal contrast, include real-time video display of fluorescence and white light image, and be simple for surgeons to use with minimal disruption of surgical flow. Rapid entry into clinical studies provides the best opportunity for early surgeon feedback, enabling development of agents and devices that will gain broad acceptance and provide information that helps surgeons achieve more complete and precise resections.

Paper Details

Date Published: 4 March 2016
PDF: 7 pages
Proc. SPIE 9696, Molecular-Guided Surgery: Molecules, Devices, and Applications II, 96960V (4 March 2016); doi: 10.1117/12.2224856
Show Author Affiliations
Heather L. Franklin, Blaze Bioscience, Inc. (United States)
Dennis M. Miller, Blaze Bioscience, Inc. (United States)
Teresa Hedges, Blaze Bioscience, Inc. (United States)
Jeff Perry, Blaze Bioscience, Inc. (United States)
Julia Parrish-Novak, Blaze Bioscience, Inc. (United States)

Published in SPIE Proceedings Vol. 9696:
Molecular-Guided Surgery: Molecules, Devices, and Applications II
Brian W. Pogue; Sylvain Gioux, Editor(s)

© SPIE. Terms of Use
Back to Top
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?