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Proceedings Paper

Visualization of vasodynamics using THz imaging with applications to allergy testing (Conference Presentation)
Author(s): Shijun Sung; Neha Bajwa; Warren Grundfest M.D.; Zachary Grundfest

Paper Abstract

This paper explores vasodynamics in response to histamine injection using reflective THz imaging. Histamine is a major contributor to allergic disease. Elevations in tissue histamine levels have been observed during anaphylaxis and experimental allergic responses of the skin, nose, and airways. In the skin specifically, vasodilation, vascular permeability, and pruritus is controlled by the release and resorption of histamine. These properties are leveraged in skin prick testing for allergies where histamine dihydrochloride is injected as a positive control to confirm allergen susceptibility prior to the administration of candidate allergens. Subjective parameters such as skin coloration, irritation, and bulging as a consequence of histamine injection and histamine release are well characterized. However limited quantitative metrics on the body’s edematous response are available due to the lack of imaging diagnostics that can map surface tissue water content (TWC). THz imaging was used to explore the utility of reflective THz imaging to quantify edematous responses to histamine. Rat models were injected with varying concentrations of histamine dihydrochloride and the resultant edematous response arising from perturbed vasodymanics was mapped. Significant build up and dissipation of surface tissue water content was observed and THz frequency contrast was seen to correlate with visual appearance in some cases and in others reveal tissue water content variations not discernable with the naked eye. The results suggest that THz imaging may be a valuable tool in quantifying the degree of allergic responses and assist in detecting hypersensitivity.

Paper Details

Date Published: 26 April 2016
PDF: 1 pages
Proc. SPIE 9706, Optical Interactions with Tissue and Cells XXVII, 97060C (26 April 2016); doi: 10.1117/12.2218576
Show Author Affiliations
Shijun Sung, Ctr. for Advanced Surgical and Interventional Technology (United States)
Neha Bajwa, Ctr. for Advanced Surgical and Interventional Technology (United States)
Warren Grundfest M.D., Ctr. for Advanced Surgical and Interventional Technology (United States)
Zachary Grundfest, Ctr. for Advanced Surgical and Interventional Technology (United States)

Published in SPIE Proceedings Vol. 9706:
Optical Interactions with Tissue and Cells XXVII
E. Duco Jansen, Editor(s)

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