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Proceedings Paper

Development and clinical translation of OTIS: a wide-field OCT imaging device for ex-vivo tissue characterization
Author(s): Elizabeth A. Munro; David Rempel; Christine Danner; Yaaseen Atchia; Michael S. Valic; Andrew Berkeley; Bahar Davoudi; Paul A. Magnin; Margarete Akens; Susan J. Done; Supriya Kulkarni; Wey-Liang Leong; Brian C. Wilson
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Paper Abstract

We have developed an automated, wide-field optical coherence tomography (OCT)-based imaging device (OTISTM Perimeter Medical Imaging) for peri-operative, ex-vivo tissue imaging. This device features automated image acquisition, enabling rapid capture of high-resolution (15 μm) OCT images from samples up to 10 cm in diameter. We report on the iterative progression of device development from phantom and pre-clinical (tumor xenograft) models through to initial clinical results. We discuss the challenges associated with proving a novel imaging technology against the clinical “gold standard” of conventional post-operative pathology.

Paper Details

Date Published: 7 March 2016
PDF: 6 pages
Proc. SPIE 9703, Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis, 97030L (7 March 2016); doi: 10.1117/12.2218467
Show Author Affiliations
Elizabeth A. Munro, Perimeter Medical Imaging (Canada)
David Rempel, Perimeter Medical Imaging (Canada)
Christine Danner, Perimeter Medical Imaging (Canada)
Yaaseen Atchia, Perimeter Medical Imaging (Canada)
Michael S. Valic, Perimeter Medical Imaging (Canada)
Andrew Berkeley, Perimeter Medical Imaging (Canada)
Bahar Davoudi, Perimeter Medical Imaging (Canada)
Paul A. Magnin, Perimeter Medical Imaging (Canada)
Margarete Akens, Univ. Health Network (Canada)
Susan J. Done, Univ. Health Network (Canada)
Supriya Kulkarni, Univ. Health Network (Canada)
Wey-Liang Leong, Univ. Health Network (Canada)
Brian C. Wilson, Univ. Health Network (Canada)

Published in SPIE Proceedings Vol. 9703:
Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis
Robert R. Alfano; Stavros G. Demos, Editor(s)

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