Share Email Print

Proceedings Paper

Hotspot detection in pancreatic neuroendocrine tumors: density approximation by α-shape maps
Author(s): M. Khalid Khan Niazi; Douglas J. Hartman; Liron Pantanowitz; Metin N. Gurcan
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

The grading of neuroendocrine tumors of the digestive system is dependent on accurate and reproducible assessment of the proliferation with the tumor, either by counting mitotic figures or counting Ki-67 positive nuclei. At the moment, most pathologists manually identify the hotspots, a practice which is tedious and irreproducible. To better help pathologists, we present an automatic method to detect all potential hotspots in neuroendocrine tumors of the digestive system. The method starts by segmenting Ki-67 positive nuclei by entropy based thresholding, followed by detection of centroids for all Ki-67 positive nuclei. Based on geodesic distance, approximated by the nuclei centroids, we compute two maps: an amoeba map and a weighted amoeba map. These maps are later combined to generate the heat map, the segmentation of which results in the hotspots. The method was trained on three and tested on nine whole slide images of neuroendocrine tumors. When evaluated by two expert pathologists, the method reached an accuracy of 92.6%. The current method does not discriminate between tumor, stromal and inflammatory nuclei. The results show that α-shape maps may represent how hotspots are perceived.

Paper Details

Date Published: 23 March 2016
PDF: 8 pages
Proc. SPIE 9791, Medical Imaging 2016: Digital Pathology, 97910B (23 March 2016); doi: 10.1117/12.2217687
Show Author Affiliations
M. Khalid Khan Niazi, The Ohio State Univ. (United States)
Douglas J. Hartman, Univ. of Pittsburgh Medical Ctr. (United States)
Liron Pantanowitz, Univ. of Pittsburgh Medical Ctr. (United States)
Metin N. Gurcan, The Ohio State Univ. (United States)

Published in SPIE Proceedings Vol. 9791:
Medical Imaging 2016: Digital Pathology
Metin N. Gurcan; Anant Madabhushi, Editor(s)

© SPIE. Terms of Use
Back to Top
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?