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Proceedings Paper

Classification of prostate cancer grade using temporal ultrasound: in vivo feasibility study
Author(s): Sahar Ghavidel; Farhad Imani; Siavash Khallaghi; Eli Gibson; Amir Khojaste; Mena Gaed; Madeleine Moussa; Jose A. Gomez; D. Robert Siemens; Michael Leveridge; Silvia Chang; Aaron Fenster; Aaron D. Ward; Purang Abolmaesumi; Parvin Mousavi
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Paper Abstract

Temporal ultrasound has been shown to have high classification accuracy in differentiating cancer from benign tissue. In this paper, we extend the temporal ultrasound method to classify lower grade Prostate Cancer (PCa) from all other grades. We use a group of nine patients with mostly lower grade PCa, where cancerous regions are also limited. A critical challenge is to train a classifier with limited aggressive cancerous tissue compared to low grade cancerous tissue. To resolve the problem of imbalanced data, we use Synthetic Minority Oversampling Technique (SMOTE) to generate synthetic samples for the minority class. We calculate spectral features of temporal ultrasound data and perform feature selection using Random Forests. In leave-one-patient-out cross-validation strategy, an area under receiver operating characteristic curve (AUC) of 0.74 is achieved with overall sensitivity and specificity of 70%. Using an unsupervised learning approach prior to proposed method improves sensitivity and AUC to 80% and 0.79. This work represents promising results to classify lower and higher grade PCa with limited cancerous training samples, using temporal ultrasound.

Paper Details

Date Published: 18 March 2016
PDF: 7 pages
Proc. SPIE 9786, Medical Imaging 2016: Image-Guided Procedures, Robotic Interventions, and Modeling, 97860K (18 March 2016); doi: 10.1117/12.2216922
Show Author Affiliations
Sahar Ghavidel, Queen's Univ. (Canada)
Farhad Imani, The Univ. of British Columbia (Canada)
Siavash Khallaghi, The Univ. of British Columbia (Canada)
Eli Gibson, Univ. College London (United Kingdom)
Amir Khojaste, Queen's Univ. (Canada)
Mena Gaed, Western Univ. (Canada)
Madeleine Moussa, London Health Sciences Ctr. (Canada)
Jose A. Gomez, London Health Sciences Ctr. (Canada)
D. Robert Siemens, Kingston General Hospital (Canada)
Michael Leveridge, Kingston General Hospital (Canada)
Silvia Chang, Vancouver General Hospital (Canada)
Aaron Fenster, Western Univ. (Canada)
Aaron D. Ward, Western Univ. (Canada)
Purang Abolmaesumi, The Univ. of British Columbia (Canada)
Parvin Mousavi, Queen's Univ. (Canada)

Published in SPIE Proceedings Vol. 9786:
Medical Imaging 2016: Image-Guided Procedures, Robotic Interventions, and Modeling
Robert J. Webster III; Ziv R. Yaniv, Editor(s)

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