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Proceedings Paper

Coronary calcium visualization using dual energy chest radiography with sliding organ registration
Author(s): Di Wen; Katelyn Nye; Bo Zhou; Robert C. Gilkeson; David L. Wilson
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Paper Abstract

Coronary artery calcification (CAC) is the lead biomarker for atherosclerotic heart disease. We are developing a new technique to image CAC using ubiquitously ordered, low cost, low radiation dual energy (DE) chest radiography (using the two-shot GE Revolution XRd system). In this paper, we proposed a novel image processing method (CorCalDx) based on sliding organ registration to create a bone-image-like, coronary calcium image (CCI) that significantly reduces motion artifacts and improves CAC conspicuity. Experiments on images of a physical dynamic cardiac phantom showed that CorCalDx reduced 73% of the motion artifact area as compared to standard DE over a range of heart rates up to 90 bpm and varying x-ray radiation exposures. Residual motion artifact in the phantom CCI is greatly suppressed in gray level and area (0.88% of the heart area). In a Functional Measurement Test (FMT) with 20 clinical exams, image quality improvement of CorCalDx against standard DE (measured from -10 to +10) was significantly suggested (p<0.0001) by three radiologists for cardiac motion artifacts (7.2±2.1) and cardiac anatomy visibility (6.1±3.5). CorCalDx was always chosen best in every image tested. In preliminary assessments of 12 patients with 18 calcifications, 90% of motion artifact regions in standard DE results were removed in CorCalDx results, with 100% sensitivity of calcification detection, showing great potential of CorCalDx to improve CAC detection and grading in DE chest radiography.

Paper Details

Date Published: 21 March 2016
PDF: 8 pages
Proc. SPIE 9784, Medical Imaging 2016: Image Processing, 97840W (21 March 2016); doi: 10.1117/12.2216436
Show Author Affiliations
Di Wen, Case Western Reserve Univ. (United States)
Katelyn Nye, GE Healthcare (United States)
Bo Zhou, Case Western Reserve Univ. (United States)
Robert C. Gilkeson, Univ. Hospitals Case Medical Ctr. (United States)
David L. Wilson, Case Western Reserve Univ. (United States)

Published in SPIE Proceedings Vol. 9784:
Medical Imaging 2016: Image Processing
Martin A. Styner; Elsa D. Angelini, Editor(s)

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