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Proceedings Paper

Breast cancer margin detection with a single frequency terahertz imaging system
Author(s): Sigfrid K. Yngvesson; Andrew Karellas; Stephen Glick; Ashraf Khan; Paul R. Siqueira; Patrick A. Kelly; Benjamin St. Peter
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Paper Abstract

The ability to discern malignant from benign tissue in excised human breast specimens in Breast Conservation Surgery (BCS) was evaluated using a prototype single frequency terahertz radiation. Terahertz (THz) images of the specimens in reflection mode were obtained by employing a gas laser source and mechanical scanning. The images were correlated with optical histological micrographs of the same specimens, and a mean discrimination of 73% was found for five out of six samples using Receiver Operating Characteristic (ROC) analysis. This result is similar to what has previously been obtained using Terahertz pulsed imaging (TPI) techniques. We will discuss the specific advantages of Single frequency THz imaging (SFTI) compared with TPI for potentially allowing the development of much faster, more compact and less expensive cancer imaging systems that could be adapted for employment in the operating room. The system design and characterization of the prototype SFTI system are discussed in detail. The initial results are encouraging but further development of the technology and clinical evaluation is needed to evaluate its feasibility in the clinical environment.

Paper Details

Date Published: 7 March 2016
PDF: 16 pages
Proc. SPIE 9706, Optical Interactions with Tissue and Cells XXVII, 970603 (7 March 2016); doi: 10.1117/12.2216385
Show Author Affiliations
Sigfrid K. Yngvesson, Univ. of Massachusetts Amherst (United States)
Andrew Karellas, Univ. of Massachusetts Medical School (United States)
Stephen Glick, U.S. Dept. of Health & Human Services (United States)
U.S. Food and Drug Administration (United States)
Ashraf Khan, Univ. of Massachusetts Medical School (United States)
Paul R. Siqueira, Univ. of Massachusetts Amherst (United States)
Patrick A. Kelly, Univ. of Massachusetts Amherst (United States)
Benjamin St. Peter, Spectral Sciences, Inc. (United States)

Published in SPIE Proceedings Vol. 9706:
Optical Interactions with Tissue and Cells XXVII
E. Duco Jansen, Editor(s)

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