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Proceedings Paper

Low cost flatbed scanner label-free biosensor
Author(s): Ugur Aygun; Oguzhan Avci; Elif Seymour; Derin D. Sevenler; Hakan Urey; M. Selim Ünlü; Ayca Yalcin Ozkumur
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Paper Abstract

In this paper, we demonstrate utilization of a commercial flatbed document scanner as a label-free biosensor for highthroughput imaging of DNA and protein microarrays. We implemented an interferometric sensing technique through use of a silicon/oxide layered substrate, and easy to implement hardware modifications such as re-aligning moving parts and inserting a custom made sample plate. With a cost as low as 100USD, powered by a USB cable, and scan speed of 30 seconds for a 4mm x 4 mm area with ~10μm lateral resolution, the presented system offers a super low cost, easy to use alternative to commercially available label-free systems.

Paper Details

Date Published: 7 March 2016
PDF: 5 pages
Proc. SPIE 9699, Optics and Biophotonics in Low-Resource Settings II, 969906 (7 March 2016); doi: 10.1117/12.2214113
Show Author Affiliations
Ugur Aygun, Koç Univ. (Turkey)
Oguzhan Avci, Boston Univ. (United States)
Elif Seymour, Boston Univ. (United States)
Derin D. Sevenler, Boston Univ. (United States)
Hakan Urey, Koç Univ. (Turkey)
M. Selim Ünlü, Boston Univ. (United States)
Ayca Yalcin Ozkumur, Bahcesehir Univ. (Turkey)

Published in SPIE Proceedings Vol. 9699:
Optics and Biophotonics in Low-Resource Settings II
David Levitz; Aydogan Ozcan; David Erickson, Editor(s)

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