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Proceedings Paper

Wide-field optical coherence elastography for intraoperative assessment of tumour margins in breast cancer (Conference Presentation)
Author(s): Wes M. Allen; Lixin Chin; David D. Sampson; Brendan F. Kennedy

Paper Abstract

Incomplete excision of tumour margins is a major issue in breast-conserving surgery. Currently 20 – 60% of cases require a second surgical procedure required as a result of cancer recurrence. A number of techniques have been proposed to assess margin status, including frozen section analysis and imprint cytology. However, the recurrence rate after using these techniques remains very high. Over the last several years, our group has been developing optical coherence elastography (OCE) as a tool for the intraoperative assessment of tumour margins in breast cancer. We have reported a feasibility study on 65 ex vivo samples from patients undergoing mastectomy or wide local excision demonstrates the potential of OCE in differentiating benign from malignant tissue. In this study, malignant tissue was readily distinguished from surrounding relative tissue by a distinctive heterogeneous pattern in micro-elastograms. To date the largest field of view for a micro-elastogram is 20 x 20mm, however, lumpectomy samples are typically ~50 x 50 x 30mm. For OCE to progress as a useful clinical tool, elastograms must be acquired over larger areas to allow a greater portion of the surface area of lumpectomies to be assessed. Here, we propose a wide-field OCE scanner that utilizes a piezoelectric transducer with an internal diameter of 65mm. In this approach partially overlapped elastograms are stitched together forming a mosaic with overall dimensions of 50 x 50mm in a total acquisition time of 15 - 30 minutes. We present results using this approach on both tissue-mimicking phantoms and tissue, and discuss prospects for shorter acquisitions times.

Paper Details

Date Published: 27 April 2016
PDF: 1 pages
Proc. SPIE 9710, Optical Elastography and Tissue Biomechanics III, 97101B (27 April 2016); doi: 10.1117/12.2213916
Show Author Affiliations
Wes M. Allen, The Univ. of Western Australia (Australia)
Lixin Chin, The Univ. of Western Australia (Australia)
David D. Sampson, The Univ. of Western Australia (Australia)
Brendan F. Kennedy, The Univ. of Western Australia (Australia)

Published in SPIE Proceedings Vol. 9710:
Optical Elastography and Tissue Biomechanics III
Kirill V. Larin; David D. Sampson, Editor(s)

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