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Proceedings Paper

Optical probes for molecular-guided surgery: Using photomedicine to prevent recurrence in the surgical bed (Conference Presentation)
Author(s): Bryan Q. Spring; R. Bryan Sears; Lei Z. Zheng; Zhiming Mai; Reika Watanabe; Elizabeth Villa; Tayyaba Hasan

Paper Abstract

Residual tumor deposits missed by conventional treatments frequently seed local and distal recurrence utilizing a network of molecular signaling mechanisms. Beyond providing contrast for molecular-guided surgery, this talk will highlight new concepts in phototherapy to address residual cancer cells in danger zones of recurrence, including selective treatment of microscopic disease using molecular-targeted, activatable immunoconjugates, and photo-initiated release of multikinase inhibitors that suppress multiple modes of tumor escape using optically active nanoparticles. These new approaches support an expanded role for the use of light in fluorescence-guided surgery—for phototherapy and for focused drug release to maximize tumor debulking with suppression of disease recurrence.

Paper Details

Date Published: 26 April 2016
PDF: 1 pages
Proc. SPIE 9696, Molecular-Guided Surgery: Molecules, Devices, and Applications II, 96960B (26 April 2016); doi: 10.1117/12.2213885
Show Author Affiliations
Bryan Q. Spring, Massachusetts General Hospital (United States)
R. Bryan Sears, Massachusetts General Hospital (United States)
Lei Z. Zheng, Massachusetts General Hospital (United States)
Zhiming Mai, Massachusetts General Hospital (United States)
Reika Watanabe, Univ. of California, San Diego (United States)
Elizabeth Villa, Univ. of California, San Diego (United States)
Tayyaba Hasan, Massachusetts General Hospital (United States)

Published in SPIE Proceedings Vol. 9696:
Molecular-Guided Surgery: Molecules, Devices, and Applications II
Brian W. Pogue; Sylvain Gioux, Editor(s)

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