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Proceedings Paper

Crowding, dynamics and transcription (Conference Presentation)
Author(s): Igal Szleifer

Paper Abstract

Biophotonic studies based on partial wave spectroscopy have shown that early carcinogenesis is characterized by a change in the nanoscale molecular organization of the cell nuclii. These finding suggest that cancer is associated with change in macromolecular crowding. In this presentation we will discuss a recent approach that we have developed to incorporate molecular scale information into a systems based approach to study the role of macromolecular crowding on different phenomena ranging from protein diffusion to gene transcription. Macromolecular crowding affects both dynamics and equilibrium properties. We will show that transcription is a non-monotonic function of crowders concentration in the cell nuclei. Furthermore, we will show how changes in macromolecular crowding in the nuclei and in the cytoplasm lead to different changes in the oscillatory behavior on NF-κB upon stimuli. Our results show the important regulatory role that non-specific interactions play in biological systems.

Paper Details

Date Published: 27 April 2016
PDF: 1 pages
Proc. SPIE 9719, Biophysics, Biology, and Biophotonics: the Crossroads, 971908 (27 April 2016); doi: 10.1117/12.2213461
Show Author Affiliations
Igal Szleifer, Northwestern Univ. (United States)

Published in SPIE Proceedings Vol. 9719:
Biophysics, Biology, and Biophotonics: the Crossroads
Adam Wax; Vadim Backman, Editor(s)

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