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Proceedings Paper

A method for tuning the excitation wavelength of an LED light source during fluorescence-based cystoscopy (Conference Presentation)

Paper Abstract

In clinical applications of fluorescence-guided endoscopy of the bladder (cystoscopy) it can be observed that the contrast in light from autofluorescence and from photodynamic diagnosis (PDD) varies from patient to patient. To compensate for this effect, a new method is presented for tuning the wavelength of a LED-based light source during fluorescence guided endoscopy of the bladder i.e. photodynamic diagnosis of bladder tumours. In the present embodiment, the wavelength of the LED source, developed in our laboratory, can be tuned to vary the excitation wavelength of both the sensitised fluorescence in the tumours (PDD) as well as the native fluorescence of the bladder mucosa and blood vessels. The contrast of the image observed through the CCD-camera attached to the cystoscope is thereby increased. In this way, patient to patient variations in autofluorescence and in sensitised fluorescence of tumours can be compensated for during fluorescence-guided cystoscopy in the clinic.

Paper Details

Date Published: 27 April 2016
PDF: 1 pages
Proc. SPIE 9689, Photonic Therapeutics and Diagnostics XII, 96891P (27 April 2016); doi: 10.1117/12.2213412
Show Author Affiliations
Lars R. Lindvold, DTU Risø Campus (Denmark)
Gregers G. Hermannn M.D., Frederiksberg Hospital (Denmark)

Published in SPIE Proceedings Vol. 9689:
Photonic Therapeutics and Diagnostics XII
Hyun Wook Kang; Guillermo J. Tearney M.D.; Melissa C. Skala; Bernard Choi; Andreas Mandelis; Brian J. F. Wong M.D.; Justus F. Ilgner M.D.; Nikiforos Kollias; Paul J. Campagnola; Kenton W. Gregory M.D.; Laura Marcu; Haishan Zeng, Editor(s)

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