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Proceedings Paper

Cervical collagen imaging for determining preterm labor risks using a colposcope with full Mueller matrix capability
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Paper Abstract

Preterm birth is a worldwide health issue, as the number one cause of infant mortality and neurological disorders. Although affecting nearly 10% of all births, an accurate, reliable diagnostic method for preterm birth has, yet, to be developed. The primary constituent of the cervix, collagen, provides the structural support and mechanical strength to maintain cervical closure, through specific organization, during fetal gestation. As pregnancy progresses, the disorganization of the cervical collagen occurs to allow eventual cervical pliability so the baby can be birthed through the cervical opening. This disorganization of collagen affects the mechanical properties of the cervix and, if the changes occur prematurely, may be a significant factor leading to preterm birth. The organization of collagen can be analyzed through the use of Mueller Matrix Polarimetric imaging of the characteristic birefringence of collagen. In this research, we have built a full Mueller Matrix Polarimetry attachment to a standard colposcope to enable imaging of human cervixes during standard prenatal exams at various stages of fetal gestation. Analysis of the polarimetric images provides information of quantity and organization of cervical collagen at specific gestational stages of pregnancy. This quantitative information may provide an indication of risk of preterm birth.

Paper Details

Date Published: 8 March 2016
PDF: 5 pages
Proc. SPIE 9689, Photonic Therapeutics and Diagnostics XII, 968947 (8 March 2016); doi: 10.1117/12.2213387
Show Author Affiliations
Susan Stoff, Florida International Univ. (United States)
Joseph Chue-Sang, Florida International Univ. (United States)
Nola A. Holness, Florida International Univ. (United States)
Amir Gandjbakhche, National Institute of Child Health and Human Development (United States)
Viktor Chernomordik, National Institute of Child Health and Human Development (United States)
Jessica Ramella-Roman, Florida International Univ. (United States)

Published in SPIE Proceedings Vol. 9689:
Photonic Therapeutics and Diagnostics XII
Hyun Wook Kang; Guillermo J. Tearney M.D.; Melissa C. Skala; Bernard Choi; Andreas Mandelis; Brian J. F. Wong M.D.; Justus F. Ilgner M.D.; Nikiforos Kollias; Paul J. Campagnola; Kenton W. Gregory M.D.; Laura Marcu; Haishan Zeng, Editor(s)

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