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Proceedings Paper

Development of microfluidic-based cell collection devices for in vitro and in vivo use
Author(s): Logan Butt; Dave Entenberg; L. P. Madhubhani Hemachandra; Matthew Strohmayer; Patricia Keely; Julio Aguirre-Ghiso; John S. Condeelis; James Castracane
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Paper Abstract

The NANIVID – or Nano Intravital Device – is an implantable delivery tool designed to locally affect the tumor microenvironment in vivo. This technology is being redesigned and validated as a cell collection tool for the study of metastatic cancer cells. A methodology has been developed to facilitate this transition, consisting of microfluidic analysis of the device microchannels and a series of cell-related collection experiments building up to in vivo collection. Single-chamber designs were first used to qualitatively demonstrate the feasibility of cell collection ex vivo. This was followed by the development and implementation of devices containing a second, negative-control chamber for quantitative analysis. This work sets the foundation for in vivo cancer cell migration studies utilizing the NANIVID.

Paper Details

Date Published: 21 March 2016
PDF: 6 pages
Proc. SPIE 9705, Microfluidics, BioMEMS, and Medical Microsystems XIV, 97051A (21 March 2016); doi: 10.1117/12.2213316
Show Author Affiliations
Logan Butt, SUNY Polytechnic Institute (United States)
Dave Entenberg, Albert Einstein College of Medicine (United States)
L. P. Madhubhani Hemachandra, SUNY Polytechnic Institute (United States)
Matthew Strohmayer, SUNY Polytechnic Institute (United States)
Patricia Keely, Univ. of Wisconsin-Madison (United States)
Julio Aguirre-Ghiso, Icahn School of Medicine at Mount Sinai (United States)
John S. Condeelis, Albert Einstein College of Medicine (United States)
James Castracane, SUNY Polytechnic Institute (United States)

Published in SPIE Proceedings Vol. 9705:
Microfluidics, BioMEMS, and Medical Microsystems XIV
Bonnie L. Gray; Holger Becker, Editor(s)

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