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Proceedings Paper

Photoacoustic imaging of inflammatory arthritis in human joints
Author(s): Janggun Jo; Guan Xu; April Marquardt; Sheeja Francis; Jie Yuan; Dhanuj Girish; Gandikota Girish; Xueding Wang
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Paper Abstract

The ducal imaging with photoacoustic imaging (PAI) that is an emerging technology and clinical ultrasound imaging that is an established modality is developed for the imaging of early inflammatory arthritis. PAI is sensitive to blood volume, not limited by flow like ultrasound, holding great promise for the earliest detection of increase in blood volume and angiogenesis - a key early finding inflammation PAI has the capability of assessing inflammation in superficial human soft tissues, offering potential benefits in diagnosis, treatment and monitoring of inflammatory arthritis. PAI combined with ultrasonography (US), is a real time dual-modality system developed and tested to identify active synovitis in metacarpophalangeal (MCP) joints of 10 arthritis patients and 10 normal volunteers. Photoacoustic images of the joints were acquired at 580-nm laser wavelength, which provided the desired balance between the optical contrast of hemoglobin over bone cortex and the imaging depth. Confirmed by US Doppler imaging, the results from ten patients and ten normal volunteers demonstrated satisfactory sensitivity of PAI in assessing enhanced blood flow due to active synovitis. This preliminary study suggests that photoacoustic imaging, by identifying early increase in blood volume, related to increased vascularity, a hallmark of joint inflammation, could be a valuable supplement to musculoskeletal US.

Paper Details

Date Published: 29 February 2016
PDF: 7 pages
Proc. SPIE 9689, Photonic Therapeutics and Diagnostics XII, 96894H (29 February 2016); doi: 10.1117/12.2213151
Show Author Affiliations
Janggun Jo, Univ. of Michigan (United States)
Guan Xu, Univ. of Michigan (United States)
April Marquardt, Univ. of Michigan (United States)
Sheeja Francis, Univ. of Michigan (United States)
Jie Yuan, Nanjing Univ. (China)
Dhanuj Girish, Huron High School (United States)
Gandikota Girish, Univ. of Michigan (United States)
Xueding Wang, Univ. of Michigan (United States)

Published in SPIE Proceedings Vol. 9689:
Photonic Therapeutics and Diagnostics XII
Hyun Wook Kang; Guillermo J. Tearney M.D.; Melissa C. Skala; Bernard Choi; Andreas Mandelis; Brian J. F. Wong M.D.; Justus F. Ilgner M.D.; Nikiforos Kollias; Paul J. Campagnola; Kenton W. Gregory M.D.; Laura Marcu; Haishan Zeng, Editor(s)

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