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Proceedings Paper

Highly sensitive protein detection using a plasmonic field effect transistor (Conference Presentation)
Author(s): Hossein Shokri-Kojori; Yiwen Ji; Xu Han; Younghun Paik; Adam Braunschweig; Sung Jin Kim

Paper Abstract

Localized surface Plasmon Resonance (LSPR) is a nanoscale phenomenon which presents strong resonance associated with noble metal nanostructures. This plasmon resonance based technology enables highly sensitive detection for chemical and biological applications. Recently, we have developed a plasmon field effect transistor (FET) that enables direct plasmonic-to-electric signal conversion with signal amplification. The plasmon FET consists of back-gated field effect transistor incorporated with gold nanoparticles on top of the FET channel. The gold nanostructures are physically separated from transistor electrodes and can be functionalized for a specific biological application. In this presentation, we report a successful demonstration of a model system to detect Con A proteins using Carbohydrate linkers as a capture molecule. The plasmon FET detected a very low concentration of Con A (0.006 mg/L) while it offers a wide dynamic range of 0.006-50 mg/L. In this demonstration, we used two-color light sources instead of a bulky spectrometer to achieve high sensitivity and wide dynamic range. The details of two-color based differential measurement method will be discussed. This novel protein-based sensor has several advantages such as extremely small size for point-of-care system, multiplexing capability, no need of complex optical geometry.

Paper Details

Date Published: 27 April 2016
PDF: 1 pages
Proc. SPIE 9721, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIII, 972104 (27 April 2016); doi: 10.1117/12.2212975
Show Author Affiliations
Hossein Shokri-Kojori, Univ. of Miami (United States)
Yiwen Ji, Univ. of Miami (United States)
Xu Han, Univ. of Miami (United States)
Younghun Paik, Univ. of Miami (United States)
Adam Braunschweig, Univ. of Miami (United States)
Sung Jin Kim, Univ. of Miami (United States)

Published in SPIE Proceedings Vol. 9721:
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIII
Alexander N. Cartwright; Dan V. Nicolau; Dror Fixler, Editor(s)

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