Share Email Print

Proceedings Paper

Plasmonic biosensor for label-free G-quadruplexes detection
Author(s): Suyan Qiu; Fusheng Zhao; Greggy M. Santos; Wei-Chuan Shih
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

G-quadruplex, readily formed by the G-rich sequence, potentially distributes in over 40 % of all human genes, such as the telomeric DNA with the G-rich sequence found at the end of the chromosome. The G-quadruplex structure is supposed to possess a diverse set of critical functions in the mammalian genome for transcriptional regulation, DNA replication and genome stability. However, most of the currently available methods for G-quadruplex identification are restricted to fluorescence techniques susceptible to poor sensitivity. It is essential to propose methods with higher sensitivity to specifically recognize the G-quadruplexes. In this study, we demonstrate a label-free plasmonic biosensor for G-quadruplex detection by relying on the advantages of nanoporous gold (NPG) disks that provide high-density plasmonic hot spots, suitable for molecular recognition capability without the requirement for labeling processes.

Paper Details

Date Published: 22 April 2016
PDF: 4 pages
Proc. SPIE 9725, Frontiers in Biological Detection: From Nanosensors to Systems VIII, 97250F (22 April 2016); doi: 10.1117/12.2212318
Show Author Affiliations
Suyan Qiu, Univ. of Houston (United States)
Fusheng Zhao, Univ. of Houston (United States)
Greggy M. Santos, Univ. of Houston (United States)
Wei-Chuan Shih, Univ. of Houston (United States)

Published in SPIE Proceedings Vol. 9725:
Frontiers in Biological Detection: From Nanosensors to Systems VIII
Benjamin L. Miller; Brian T. Cunningham, Editor(s)

© SPIE. Terms of Use
Back to Top
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?