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Proceedings Paper

Simultaneous multi-scale microscopy as a potential dedicated tool for intra-operative parathyroid identification during thyroid surgery (Conference Presentation)
Author(s): Étienne De Montigny; Nadir Goulamhoussen; Wendy-Julie Madore; Mathias Strupler; Anastasios Maniakas M.D.; Tareck Ayad M.D.; Caroline Boudoux

Paper Abstract

While thyroidectomy is considered a safe surgery, dedicated tools facilitating tissue identification during surgery could improve its outcome. The most common complication following surgery is hypocalcaemia, which results from iatrogenic removal or damage to parathyroid glands. This research project aims at developing and validating an instrument based on optical microscopy modalities to identify tissues in real time during surgery. Our approach is based on a combination of reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) to obtain multi-scale morphological contrast images. The orthogonal field of views provide information to navigate through the sample. To allow simultaneous, synchronized video-rate imaging in both modalities, we designed and built a dual-band wavelength-swept laser which scans a 30 nm band centered at 780 nm and a 90 nm band centered at 1310 nm. We built an imaging setup integrating a custom-made objective lens and a double-clad fibre coupler optimized for confocal microscopy. It features high resolutions in RCM (2µm lateral and 20 µm axial) in a 500 µm x 500 µm field-of-view and a larger field-of-view of 2 mm (lateral) x 5 mm (axial) with 20 µm lateral and axial resolutions in OCT. Imaging of ex vivo animal samples is demonstrated on a bench-top system. Tissues that are visually difficult to distinguish from each other intra-operatively such as parathyroid gland, lymph nodes and adipose tissue are imaged to show the potential of this approach in differentiating neck tissues. We will also provide an update on our ongoing clinical pilot study on patients undergoing thyroidectomy.

Paper Details

Date Published: 27 April 2016
PDF: 1 pages
Proc. SPIE 9689, Photonic Therapeutics and Diagnostics XII, 968929 (27 April 2016); doi: 10.1117/12.2211200
Show Author Affiliations
Étienne De Montigny, Ecole Polytechnique de Montréal (Canada)
Nadir Goulamhoussen, Ecole Polytechnique de Montréal (Canada)
Wendy-Julie Madore, Ecole Polytechnique de Montréal (Canada)
Mathias Strupler, Ecole Polytechnique de Montréal (Canada)
Anastasios Maniakas M.D., Montreal Univ. Health Ctr. (Canada)
Tareck Ayad M.D., Ctr. Hospitalier de l'Univ. de Montréal (Canada)
Caroline Boudoux, Ecole Polytechnique de Montréal (Canada)

Published in SPIE Proceedings Vol. 9689:
Photonic Therapeutics and Diagnostics XII
Hyun Wook Kang; Guillermo J. Tearney M.D.; Melissa C. Skala; Bernard Choi; Andreas Mandelis; Brian J. F. Wong M.D.; Justus F. Ilgner M.D.; Nikiforos Kollias; Paul J. Campagnola; Kenton W. Gregory M.D.; Laura Marcu; Haishan Zeng, Editor(s)

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