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Proceedings Paper

Clinical use of a portable dual microscope system for smartphone (Conference Presentation)
Author(s): Cristina Kurachi D.D.S.; Gabriel Brognara; Pablo A. Gómez-García; Fernanda Carbinatto; Eduardo V. Silva; Wellington Lombardi; Natália M. Inada; Vanderlei S. Bagnato

Paper Abstract

Cervical cancer is still one of the most relevant women cancer types, since the 5-year survival rate is of only around 68%. Prevention and early diagnosis are the best strategies to improve cervical cancer prognosis. Conventional diagnosis procedure in Gynecology is mainly based on the macroscopic clinical evaluation, Pap smear cytology, and biopsy, if needed. A portable microscope with dual configuration and its use for diagnosis in Gynecology is investigated. The microscope has interchangeable parts that allow its use for cytopathology smear samples or in situ endoscopic tissue interrogation, both using acriflavine as a nuclei marker. Patients of the Women Ambulatory of the School of Medicine (UNIARA, Araraquara, Brazil) were interrogated during the colposcopy examination. The cervix was initially cleaned using an acetic acid solution, and a 0.05% (wt/vol) acriflavine in saline solution was topically applied at the tissue surface using a cotton swab. Microendoscopy images were taken from clinically normal cervix mucosa and from detected lesions. An image processing is performed to evaluate the cell nuclei morphology and the cytoplasm/nuclei ratio. The Pap smear results and the histology analyses are taken as gold standard for the diagnosis. Preliminary results in 5 patients demonstrated the potential use of our microscope at the clinical setting.

Paper Details

Date Published: 27 April 2016
PDF: 1 pages
Proc. SPIE 9698, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIV, 96980E (27 April 2016); doi: 10.1117/12.2211096
Show Author Affiliations
Cristina Kurachi D.D.S., Univ. de São Paulo (Brazil)
Gabriel Brognara, Univ. de São Paulo (Brazil)
Pablo A. Gómez-García, Univ. de São Paulo (Brazil)
Fernanda Carbinatto, Univ. de São Paulo (Brazil)
Eduardo V. Silva, UNIARA (Brazil)
Wellington Lombardi, UNIARA (Brazil)
Natália M. Inada, Univ. de São Paulo (Brazil)
Vanderlei S. Bagnato, Univ. de São Paulo (Brazil)

Published in SPIE Proceedings Vol. 9698:
Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIV
Tuan Vo-Dinh; Anita Mahadevan-Jansen; Warren S. Grundfest M.D., Editor(s)

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