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Proceedings Paper

NutriPhone: vitamin B12 testing on your smartphone (Conference Presentation)
Author(s): Seoho Lee; Dakota O'Dell; Jessica Hohenstein; Susannah Colt; Saurabh Mehta; David Erickson

Paper Abstract

Vitamin B12 deficiency is the leading cause of cognitive decline in the elderly and is associated with increased risks of several acute and chronic conditions including anemia. The deficiency is prevalent among the world population, most of whom are unaware of their condition due to the lack of a simple diagnostics system. Recent advancements in the smartphone-enabled mobile health can help address this problem by making the deficiency tests more accessible. Previously, our group has demonstrated the NutriPhone, a smartphone platform for the accurate quantification of vitamin D levels. The NutriPhone technology comprises of a disposable test strip that performs a colorimetric reaction upon collecting a sample, a reusable accessory that interfaces with the smartphone camera, and a smartphone app that stores the algorithm for analyzing the test-strip reaction. In this work, we show that the NutriPhone can be expanded to measure vitamin B12 concentrations by developing a lateral flow assay for B12 that is compatible with our NutriPhone system. Our novel vitamin B12 assay incorporates blood sample processing and key reagent storage on-chip, which advances it into a sample-in-answer-out format that is suitable for point-of-care diagnostic applications. In order to enable the detection of pM levels of vitamin B12 levels, silver amplification of the initial signal is used within the total assay time of less than 15 minutes. We demonstrate the effectiveness of our NutriPhone system by deploying it in a resource-limited clinical setting in India where it is used to test tens of participants for vitamin B12 deficiency.

Paper Details

Date Published: 3 May 2016
PDF: 1 pages
Proc. SPIE 9699, Optics and Biophotonics in Low-Resource Settings II, 969904 (3 May 2016); doi: 10.1117/12.2210761
Show Author Affiliations
Seoho Lee, Cornell Univ. (United States)
Dakota O'Dell, Cornell Univ. (United States)
Jessica Hohenstein, Cornell Univ. (United States)
Susannah Colt, Cornell Univ. (United States)
Saurabh Mehta, Cornell Univ. (United States)
David Erickson, Cornell Univ. (United States)

Published in SPIE Proceedings Vol. 9699:
Optics and Biophotonics in Low-Resource Settings II
David Levitz; Aydogan Ozcan; David Erickson, Editor(s)

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