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Proceedings Paper

Temperature distribution in target tumor tissue and photothermal tissue destruction during laser immunotherapy
Author(s): Austin Doughty; Aamr Hasanjee; Alex Pettitt; Kegan Silk; Hong Liu; Wei R. Chen; Feifan Zhou
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Paper Abstract

Laser Immunotherapy is a novel cancer treatment modality that has seen much success in treating many different types of cancer, both in animal studies and in clinical trials. The treatment consists of the synergistic interaction between photothermal laser irradiation and the local injection of an immunoadjuvant. As a result of the therapy, the host immune system launches a systemic antitumor response. The photothermal effect induced by the laser irradiation has multiple effects at different temperature elevations which are all required for optimal response. Therefore, determining the temperature distribution in the target tumor during the laser irradiation in laser immunotherapy is crucial to facilitate the treatment of cancers. To investigate the temperature distribution in the target tumor, female Wistar Furth rats were injected with metastatic mammary tumor cells and, upon sufficient tumor growth, underwent laser irradiation and were monitored using thermocouples connected to locally-inserted needle probes and infrared thermography. From the study, we determined that the maximum central tumor temperature was higher for tumors of less volume. Additionally, we determined that the temperature near the edge of the tumor as measured with a thermocouple had a strong correlation with the maximum temperature value in the infrared camera measurement.

Paper Details

Date Published: 9 March 2016
PDF: 6 pages
Proc. SPIE 9709, Biophotonics and Immune Responses XI, 97090N (9 March 2016); doi: 10.1117/12.2209692
Show Author Affiliations
Austin Doughty, Univ. of Central Oklahoma (United States)
Aamr Hasanjee, Univ. of Central Oklahoma (United States)
Alex Pettitt, Univ. of Central Oklahoma (United States)
Kegan Silk, Univ. of Central Oklahoma (United States)
Hong Liu, Univ. of Oklahoma (United States)
Wei R. Chen, Univ. of Central Oklahoma (United States)
Feifan Zhou, Univ. of Central Oklahoma (United States)

Published in SPIE Proceedings Vol. 9709:
Biophotonics and Immune Responses XI
Wei R. Chen, Editor(s)

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