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Proceedings Paper

Assessing the viscoelasticity of green light induced CXL in the rabbit cornea by noncontact OCE and FEM
Author(s): Zhaolong Han; Jiasong Li; Manmohan Singh; Srilatha Vantipalli; Salavat R. Aglyamov; Chen Wu; Chih-hao Liu; Michael D. Twa; Kirill V. Larin
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Paper Abstract

The biomechanical properties of the cornea have a profound influence on its health and function. Rose bengal/green light corneal collagen cross-linking (RGX) has been proposed as an alternative to UV-A Riboflavin collagen cross-linking (UV-CXL) for treatment of keratoconus. However, the effects of RGX on the biomechanical properties of the cornea are not as well understood as UV-CXL. In this work, we demonstrate the feasibility of quantifying the viscoelasticity of the rabbit cornea before and after RGX using a noncontact method of phase-stabilized swept source optical coherence elastography (PhS-SSOCE) and finite element modeling (FEM). Viscoelastic FE models of the corneas were constructed to simulate the elastic wave propagation based on the OCE measurements. In addition, the effect of the fluid-structure interface (FSI) between the corneal posterior surface and aqueous humor on the elastic wave group velocity was also investigated. The effect of the FSI was first validated by OCE measurements and FEM simulations on contact lenses, and the OCE and FEM results were in good agreement. The Young’s modulus of the rabbit cornea before RGX was assessed as E=80 kPa, and the shear viscosity was η=0.40 Pa•s at an intraocular pressure (IOP) of 15 mmHg. After RGX, the Young’s modulus increased to E=112 kPa and shear viscosity decreased to η=0.37 Pa•s. Both the corneal OCE experiments and the FE simulations also demonstrated that the FSI significantly reduced the group velocity of the elastic wave, and thus, the FSI should be considered when determining the biomechanical properties of the cornea.

Paper Details

Date Published: 4 March 2016
PDF: 6 pages
Proc. SPIE 9693, Ophthalmic Technologies XXVI, 96930X (4 March 2016); doi: 10.1117/12.2208627
Show Author Affiliations
Zhaolong Han, Univ. of Houston (United States)
Jiasong Li, Univ. of Houston (United States)
Manmohan Singh, Univ. of Houston (United States)
Srilatha Vantipalli, Univ. of Houston (United States)
Salavat R. Aglyamov, The Univ. of Texas at Austin (United States)
Chen Wu, Univ. of Houston (United States)
Chih-hao Liu, Univ. of Houston (United States)
Michael D. Twa, The Univ. of Alabama at Birmingham (United States)
Kirill V. Larin, Univ. of Houston (United States)
Baylor College of Medicine (United States)
Tomsk State Univ. (Russian Federation)

Published in SPIE Proceedings Vol. 9693:
Ophthalmic Technologies XXVI
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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