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Proceedings Paper

Semi-automatic microdrive system for positioning electrodes during electrophysiological recordings from rat brain
Author(s): Piotr Dabrowski; Ewa Kublik; Jakub Mozaryn
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Paper Abstract

Electrophysiological recording of neuronal action potentials from behaving animals requires portable, precise and reliable devices for positioning of multiple microelectrodes in the brain. We propose a semi-automatic microdrive system for independent positioning of up to 8 electrodes (or tetrodes) in a rat (or larger animals). Device is intended to be used in chronic, long term recording applications in freely moving animals. Our design is based on independent stepper motors with lead screws which will offer single steps of ~ μm semi-automatically controlled from the computer. Microdrive system prototype for one electrode was developed and tested. Because of the lack of the systematic test procedures dedicated to such applications, we propose the evaluation of the prototype similar to ISO norm for industrial robots. To this end we designed and implemented magnetic linear and rotary encoders that provided information about electrode displacement and motor shaft movement. On the basis of these measurements we estimated repeatability, accuracy and backlash of the drive. According to the given assumptions and preliminary tests, the device should provide greater accuracy than hand-controlled manipulators available on the market. Automatic positioning will also shorten the course of the experiment and improve the acquisition of signals from multiple neuronal populations.

Paper Details

Date Published: 11 September 2015
PDF: 12 pages
Proc. SPIE 9662, Photonics Applications in Astronomy, Communications, Industry, and High-Energy Physics Experiments 2015, 96621O (11 September 2015); doi: 10.1117/12.2205806
Show Author Affiliations
Piotr Dabrowski, Warsaw Univ. of Technology (Poland)
Ewa Kublik, Nencki Institute of Experimental Biology (Poland)
Jakub Mozaryn, Warsaw Univ. of Technology (Poland)

Published in SPIE Proceedings Vol. 9662:
Photonics Applications in Astronomy, Communications, Industry, and High-Energy Physics Experiments 2015
Ryszard S. Romaniuk, Editor(s)

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