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Proceedings Paper

Tiny-TOF-MALDI mass spectrometry for particulate drug and explosives detection
Author(s): Wayne A. Bryden; Richard C. Benson; Scott A. Ecelberger; Terry E. Phillips; Timothy J. Cornish; Robert J. Cotter
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Paper Abstract

The MALDI (matrix assisted laser desorption/ionization) technique, widely used to desorb and ionize large biomolecules, is applied here to small molecules having low vapor pressure, such as drugs and explosives. Furthermore, we report the coupling of the MALDI technique with a small, highly portable tiny-TOF (fime-of-flight) mass spectrometer developed in our laboratories. This mass spectrometer is a low voltage coaxial reflectron design with a short flight tube that is specifically designed for low molecular weight substances. The reflectron is designed to operate in two different modes that provide an expremely powerful pseudo-tandem mass spectrometry capability that is crucial for field applications. Using this system we have measured mass spectral signatures for cocaine, heroine, and the explosive RDX in the sub- nanogram range. Also reported here are continued developements on advanced MALDI sampling technologies, sensitivity, and mass resolution enhancements of the tiny-TOF, further decreases in system size and weight, and concepts for field operational systems.

Paper Details

Date Published: 15 September 1995
PDF: 12 pages
Proc. SPIE 2511, Law Enforcement Technologies: Identification Technologies and Traffic Safety, (15 September 1995); doi: 10.1117/12.219599
Show Author Affiliations
Wayne A. Bryden, Johns Hopkins Univ. (United States)
Richard C. Benson, Johns Hopkins Univ. (United States)
Scott A. Ecelberger, Johns Hopkins Univ. (United States)
Terry E. Phillips, Johns Hopkins Univ. (United States)
Timothy J. Cornish, Johns Hopkins Medical Institution (United States)
Robert J. Cotter, Johns Hopkins Medical Institution (United States)

Published in SPIE Proceedings Vol. 2511:
Law Enforcement Technologies: Identification Technologies and Traffic Safety
Bernard Dubuisson; Geoffrey L. Harding, Editor(s)

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