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Proceedings Paper

Determination of glucose concentration based on pulsed laser induced photoacoustic technique and least square fitting algorithm
Author(s): Zhong Ren; Guodong Liu; Zhen Huang
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Paper Abstract

In this paper, a noninvasive glucose concentration monitoring setup based on the photoacoustic technique was established. In this setup, a 532nm pumped Q switched Nd: YAG tunable pulsed laser with repetition rate of 20Hz was used as the photoacoustic excitation light source, and a ultrasonic transducer with central response frequency of 9.55MHz was used as the detector of the photoacoustic signal of glucose. As the preliminary exploration of the blood glucose concentration, a series of in vitro photoacoustic monitoring of glucose aqueous solutions by using the established photoacoustic setup were performed. The photoacoustic peak-to-peak values of different concentrations of glucose aqueous solutions induced by the pulsed laser with output wavelength of 1300nm to 2300nm in interval of 10nm were obtained with the average times of 512. The differential spectral and the first order derivative spectral method were used to get the characteristic wavelengths. For the characteristic wavelengths of glucose, the least square fitting algorithm was used to establish the relationship between the glucose concentrations and photoacoustic peak-to-peak values. The characteristic wavelengths and the predicted concentrations of glucose solution were obtained. Experimental results demonstrated that the prediction effect of characteristic wavelengths of 1410nm and 1510nm were better than others, and this photoacoustic setup and analysis method had a certain potential value in the monitoring of the blood glucose concentration.

Paper Details

Date Published: 5 August 2015
PDF: 8 pages
Proc. SPIE 9619, 2015 International Conference on Optical Instruments and Technology: Optoelectronic Devices and Optical Signal Processing, 96190M (5 August 2015); doi: 10.1117/12.2190601
Show Author Affiliations
Zhong Ren, Jiangxi Science and Technology Normal Univ. (China)
Nanchang Univ. (China)
Guodong Liu, Jiangxi Science and Technology Normal Univ. (China)
Zhen Huang, Jiangxi Science and Technology Normal Univ. (China)

Published in SPIE Proceedings Vol. 9619:
2015 International Conference on Optical Instruments and Technology: Optoelectronic Devices and Optical Signal Processing
Yi Dong; Chao Lu; Jian Wu; Zhaohui Li, Editor(s)

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