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Proceedings Paper

Early diagnosis of tongue malignancy using laser induced fluorescence spectroscopy technique
Author(s): Ajeetkumar Patil; Unnikrishnan V. K.; Ravikiran Ongole; Keerthilatha M. Pai; V. B. Kartha; Santhosh Chidangil
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Paper Abstract

Oral cancer together with pharyngeal cancer is the sixth most common malignancy reported worldwide and one with high mortality ratio among all malignancies [1]. Worldwide 450,000 new cases are estimated in 2014[2]. About 90% are a type of cancer called squamous cell carcinoma (SCC). SCC of the tongue is the most common oral malignancy accounting for approximately 40% of all oral carcinomas. One of the important factors for successful therapy of any malignancy is early diagnosis. Although considerable progress has been made in understanding the cellular and molecular mechanisms of tumorigenesis, lack of reliable diagnostic methods for early detection leading to delay in therapy is an important factor responsible for the increase in the mortality rate in various types of cancers. Spectroscopy techniques are extremely sensitive for the analysis of biochemical changes in cellular systems. These techniques can provide a valuable information on alterations that occur during the development of cancer. This is especially important in oral cancer, where "tumor detection is complicated by a tendency towards field cancerization, leading to multi-centric lesions" and "current techniques detect malignant change too late" [3], and "biopsies are not representative of the whole premalignant lesion". [4]

Paper Details

Date Published: 15 July 2015
PDF: 5 pages
Proc. SPIE 9537, Clinical and Biomedical Spectroscopy and Imaging IV, 95370J (15 July 2015); doi: 10.1117/12.2184964
Show Author Affiliations
Ajeetkumar Patil, Manipal Univ. (India)
Unnikrishnan V. K., Manipal Univ. (India)
Ravikiran Ongole, Manipal Univ. (India)
Keerthilatha M. Pai, Manipal Univ. (India)
V. B. Kartha, Manipal Univ. (India)
Santhosh Chidangil, Manipal Univ. (India)

Published in SPIE Proceedings Vol. 9537:
Clinical and Biomedical Spectroscopy and Imaging IV
J. Quincy Brown; Volker Deckert, Editor(s)

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