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Proceedings Paper

Development of a movable diffuse reflectance spectroscopy system for clinical study of esophageal precancer
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Paper Abstract

We constructed a movable imaging spectrograph-based system and a contact probe consisting of fibers with several source-to-detection separations (SDS) to measure spatially-resolved diffuse reflectance spectra from superficial tissue. The goal is to estimate optical properties of the mucosa in the oral cavity and investigate correlations between the estimated properties and precancerous changes in the mucosa. A previously developed GPU-based iterative curve-fitting inverse Monte Carlo model was used to extract optical properties from measured spectra. We validated the system with two-layer tissue phantoms, took in-vivo measurements on the buccal mucosa of three normal volunteers, and extracted optical parameters.

Paper Details

Date Published: 15 July 2015
PDF: 6 pages
Proc. SPIE 9537, Clinical and Biomedical Spectroscopy and Imaging IV, 95371Q (15 July 2015); doi: 10.1117/12.2183737
Show Author Affiliations
Yi-Hsien Hsiao, National Taiwan Univ. (Taiwan)
Gen-Hao Tien, National Taiwan Univ. (Taiwan)
Min-Jie Chuang, National Taiwan Univ. (Taiwan)
Fang-Wei Hsu, National Taiwan Univ. (Taiwan)
Hong-Po Hsieh, National Taiwan Univ. (Taiwan)
Kung-Bin Sung, National Taiwan Univ. (Taiwan)

Published in SPIE Proceedings Vol. 9537:
Clinical and Biomedical Spectroscopy and Imaging IV
J. Quincy Brown; Volker Deckert, Editor(s)

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