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Proceedings Paper

Raman spectroscopy of stored red blood cells: evaluating clinically-relevant biochemical markers in donated blood
Author(s): Chad G. Atkins; Kevin Buckley; Deborah Chen; H. Georg Schulze; Dana V. Devine; Michael W. Blades; Robin F. B. Turner
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Paper Abstract

Modern transfusion medicine relies on the safe, secure, and cost-effective delivery of donated red blood cells (RBCs). Once isolated, RBCs are suspended in a defined additive solution and stored in plastic blood bags in which, over time, they undergo chemical, physiological, and morphological changes that may have a deleterious impact on some patients. Regulations limit the storage period to 42 days and the cells do not routinely undergo analytical testing before use. In this study, we use Raman spectroscopy to interrogate stored RBCs and we identify metabolic and cell-breakdown products, such as haemoglobin and membrane fragments, that build-up in the blood bags as the cells age. Our work points the way to the development of an instrument which could quickly and easily assess the biochemical nature of stored RBC units before they are transfused.

Paper Details

Date Published: 15 July 2015
PDF: 7 pages
Proc. SPIE 9537, Clinical and Biomedical Spectroscopy and Imaging IV, 95370X (15 July 2015); doi: 10.1117/12.2183598
Show Author Affiliations
Chad G. Atkins, The Univ. of British Columbia (Canada)
Kevin Buckley, The Univ. of British Columbia (Canada)
Deborah Chen, The Univ. of British Columbia (Canada)
H. Georg Schulze, The Univ. of British Columbia (Canada)
Dana V. Devine, The Univ. of British Columbia (Canada)
Michael W. Blades, The Univ. of British Columbia (Canada)
Robin F. B. Turner, The Univ. of British Columbia (Canada)


Published in SPIE Proceedings Vol. 9537:
Clinical and Biomedical Spectroscopy and Imaging IV
J. Quincy Brown; Volker Deckert, Editor(s)

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